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fry furry [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39122, updated on 9-Dec-2024

Summary

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Official Symbol
fryprovided by FlyBase
Official Full Name
furryprovided by FlyBase
Primary source
FLYBASE:FBgn0016081
Locus tag
Dmel_CG32045
See related
AllianceGenome:FB:FBgn0016081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14171; CG32045; CG6774; CG6780; Dmel\CG32045; Fry; l(3)02240; RE-B; SS3-7; yeti
Summary
Involved in several processes, including neuron differentiation; positive regulation of macromolecule metabolic process; and regulation of cell projection organization. Located in several cellular components, including apical part of cell; cell body; and dendrite. Is expressed in adult head; follicle cell; and spermatozoon. Used to study syndromic intellectual disability. Orthologous to human FRYL (FRY like transcription coactivator) and FRY (FRY microtubule binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See fry in Genome Data Viewer
Location:
67C3-67C4; 3-31 cM
Exon count:
31
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9631834..9679103, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9624934..9672203, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 67b Neighboring gene Cyclophilin 40 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene CNMamide Receptor Neighboring gene alpha-Tubulin at 67C Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features. Pan X, et al. Am J Hum Genet, 2024 Apr 4. PMID 38479391, Free PMC Article
  2. The Drosophila Fry protein interacts with Trc and is highly mobile in vivo. Fang X, et al. BMC Dev Biol, 2010 Apr 20. PMID 20406475, Free PMC Article
  3. Dendritic tiling; new insights from genetics. Zinn K. Neuron, 2004 Oct 14. PMID 15473957
  4. A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation. Horne-Badovinac S, et al. G3 (Bethesda), 2012 Mar. PMID 22413091, Free PMC Article
  5. Role of self-avoidance in neuronal wiring. Kise Y, et al. Curr Opin Neurobiol, 2013 Dec. PMID 24161734

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in antennal morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite self-avoidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in imaginal disc-derived wing hair organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule sliding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection arborization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-sensory hair organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
furry
Names
CG32045-PB
CG32045-PC
CG32045-PE
CG32045-PF
CG32045-PG
CG32045-PH
CG32045-PI
CG32045-PJ
fry-PB
fry-PC
fry-PE
fry-PF
fry-PG
fry-PH
fry-PI
fry-PJ
suppressor of GMR-sina 3-7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9631834..9679103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168357.3 → NP_729520.1  furry, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729520.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E8G4, Q8T9A1, Q9BIR5, Q9GPT8, Q9VT28
    Related
    FBpp0076146
    Conserved Domains (3) summary
    pfam14222
    Location:389 → 923
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2453 → 2705
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1278 → 2050
    MOR2-PAG1_mid; Cell morphogenesis central region

  2. NM_001274710.1 → NP_001261639.1  furry, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261639.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF44
    Conserved Domains (3) summary
    pfam14222
    Location:389 → 923
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2453 → 2705
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1278 → 2050
    MOR2-PAG1_mid; Cell morphogenesis central region

  3. NM_001259771.1 → NP_001246700.1  furry, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246700.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFQ5
    Conserved Domains (3) summary
    pfam14222
    Location:389 → 923
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2453 → 2705
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1278 → 2050
    MOR2-PAG1_mid; Cell morphogenesis central region

  4. NM_168356.2 → NP_729519.2  furry, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729519.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCY4
    Conserved Domains (3) summary
    pfam14222
    Location:389 → 923
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2501 → 2753
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1326 → 2098
    MOR2-PAG1_mid; Cell morphogenesis central region

  5. NM_001259772.1 → NP_001246701.1  furry, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246701.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9ND72
    Conserved Domains (3) summary
    pfam14222
    Location:389 → 923
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2501 → 2753
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1326 → 2098
    MOR2-PAG1_mid; Cell morphogenesis central region

  6. NM_001274709.1 → NP_001261638.1  furry, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261638.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEP1
    Conserved Domains (3) summary
    pfam14222
    Location:389 → 923
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2501 → 2753
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1326 → 2098
    MOR2-PAG1_mid; Cell morphogenesis central region

  7. NM_001274708.1 → NP_001261637.1  furry, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261637.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PC07
    Conserved Domains (3) summary
    pfam14222
    Location:384 → 918
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2448 → 2700
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1273 → 2045
    MOR2-PAG1_mid; Cell morphogenesis central region

  8. NM_001259770.1 → NP_001246699.1  furry, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246699.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NE70
    Conserved Domains (3) summary
    pfam14222
    Location:384 → 918
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2496 → 2748
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1321 → 2093
    MOR2-PAG1_mid; Cell morphogenesis central region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QCY4 E2QCY4
M9ND72 M9ND72
M9NE70 M9NE70
M9NFQ5 M9NFQ5
M9PC07 M9PC07
M9PEP1 M9PEP1
M9PF44 M9PF44
Q9VT28.2 Q9VT28

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