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Cyp40 Cyclophilin 40 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39121, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp40provided by FlyBase
Official Full Name
Cyclophilin 40provided by FlyBase
Primary source
FLYBASE:FBgn0036020
Locus tag
Dmel_CG8336
See related
AllianceGenome:FB:FBgn0036020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8336; Dmel\CG8336
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in RISC complex assembly; piRNA processing; and piRNA-mediated gene silencing by mRNA destabilization. Acts upstream of with a positive effect on spermatogenesis. Part of protein folding chaperone complex. Is active in cytosol. Is expressed in adult head; organism; spermatogonium; and testis. Orthologous to human PPID (peptidylprolyl isomerase D). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Cyp40 in Genome Data Viewer
Location:
67C2-67C3; 3-31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9628676..9631795)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9621776..9624895)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Laminin B2 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 67b Neighboring gene furry Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Odorant receptor polymorphisms and natural variation in olfactory behavior in Drosophila melanogaster. Rollmann SM, et al. Genetics, 2010 Oct. PMID 20628035, Free PMC Article
  2. miRNA/siRNA-directed pathway to produce noncoding piRNAs from endogenous protein-coding regions ensures Drosophila spermatogenesis. Iki T, et al. Sci Adv, 2023 Jul 21. PMID 37467338, Free PMC Article
  3. Modulation of Ago2 Loading by Cyclophilin 40 Endows a Unique Repertoire of Functional miRNAs during Sperm Maturation in Drosophila. Iki T, et al. Cell Rep, 2020 Nov 10. PMID 33176138
  4. Dynamics of nuclear matrix proteome during embryonic development in Drosophila melanogaster. Varma P, et al. J Biosci, 2011 Aug. PMID 21799256
  5. Selection for cold resistance alters gene transcript levels in Drosophila melanogaster. Telonis-Scott M, et al. J Insect Physiol, 2009 Jun. PMID 19232407

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RISC complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in piRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piRNA-mediated gene silencing by mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_positive_effect spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein folding chaperone complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclophilin 40
Names
CG8336-PA
CG8336-PB
CG8336-PC
CG8336-PD
Cyp40-PA
Cyp40-PB
Cyp40-PC
Cyp40-PD
NP_001261636.1
NP_648338.1
NP_729517.1
NP_729518.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9628676..9631795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168354.2 → NP_729517.1  cyclophilin 40, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729517.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT21
    Related
    FBpp0076113
    Conserved Domains (4) summary
    sd00006
    Location:285 → 315
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:320 → 353
    TPR_1; Tetratricopeptide repeat
    pfam14559
    Location:300 → 369
    TPR_19; Tetratricopeptide repeat
    cl00197
    Location:15 → 181
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

  2. NM_140081.3 → NP_648338.1  cyclophilin 40, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648338.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT21
    Related
    FBpp0076114
    Conserved Domains (4) summary
    sd00006
    Location:285 → 315
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:320 → 353
    TPR_1; Tetratricopeptide repeat
    pfam14559
    Location:300 → 369
    TPR_19; Tetratricopeptide repeat
    cl00197
    Location:15 → 181
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

  3. NM_168355.3 → NP_729518.1  cyclophilin 40, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729518.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT21
    Related
    FBpp0076115
    Conserved Domains (4) summary
    sd00006
    Location:285 → 315
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:320 → 353
    TPR_1; Tetratricopeptide repeat
    pfam14559
    Location:300 → 369
    TPR_19; Tetratricopeptide repeat
    cl00197
    Location:15 → 181
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

  4. NM_001274707.1 → NP_001261636.1  cyclophilin 40, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261636.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT21
    Conserved Domains (4) summary
    sd00006
    Location:285 → 315
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:320 → 353
    TPR_1; Tetratricopeptide repeat
    pfam14559
    Location:300 → 369
    TPR_19; Tetratricopeptide repeat
    cl00197
    Location:15 → 181
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VT21 Q9VT21

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