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PLA2G2C phospholipase A2 group IIC [ Homo sapiens (human) ]

Gene ID: 391013, updated on 10-Dec-2024

Summary

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Official Symbol
PLA2G2Cprovided by HGNC
Official Full Name
phospholipase A2 group IICprovided by HGNC
Primary source
HGNC:HGNC:9032
See related
Ensembl:ENSG00000187980 AllianceGenome:HGNC:9032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBXN10-AS1
Summary
Predicted to enable several functions, including calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in fatty acid biosynthetic process; phospholipid metabolic process; and positive regulation of fibroblast proliferation. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See PLA2G2C in Genome Data Viewer
Location:
1p36.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20163055..20186518, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (19986700..20010162, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20489548..20513011, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20468424-20468924 Neighboring gene phospholipase A2 group IIF Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20474795-20475295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20476004-20476630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20479806-20480357 Neighboring gene uncharacterized LOC117779438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 316 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:20511679-20512878 Neighboring gene UBX domain protein 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 317 Neighboring gene uncharacterized LOC105376825 Neighboring gene uncharacterized LOC105376826 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:20537509-20538708

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis. Tang Y, et al. Bioengineered, 2022 Feb. PMID 35034539, Free PMC Article
  2. Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. Tischfield JA, et al. Genomics, 1996 Mar 15. PMID 8838795
  3. HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes. Mavoungou E, et al. J Acquir Immune Defic Syndr Hum Retrovirol, 1997 Sep 1. PMID 9377118
  4. Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. Schröder HC, et al. Neurotoxicology, 1998 Aug-Oct. PMID 9745929
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis.
    Title: LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative inactive group IIC secretory phospholipase A2
Names
UBXN10 antisense RNA 1
phosphatidylcholine 2-acylhydrolase-like protein GIIC
phospholipase A2, group IIC (possible pseudogene)
NP_001303651.1
NP_001354898.1
XP_047276172.1
XP_054192510.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316722.3 → NP_001303651.1  putative inactive group IIC secretory phospholipase A2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    Z98257
    UniProtKB/TrEMBL
    J3KMZ3
    Conserved Domains (1) summary
    pfam00068
    Location:22 → 132
    Phospholip_A2_1; Phospholipase A2

  2. NM_001367969.2 → NP_001354898.1  putative inactive group IIC secretory phospholipase A2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    Z98257
    Consensus CDS
    CCDS90872.1
    UniProtKB/Swiss-Prot
    Q5R387, Q7M4M6
    UniProtKB/TrEMBL
    J3KMZ3
    Related
    ENSP00000504292.1, ENST00000679259.1

RNA

  1. NR_110078.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    Z98257
    Related
    ENST00000442226.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    20163055..20186518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420216.1 → XP_047276172.1  putative inactive group IIC secretory phospholipase A2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    19986700..20010162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336535.1 → XP_054192510.1  putative inactive group IIC secretory phospholipase A2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105572.1: Suppressed sequence

    Description
    NM_001105572.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5R387.3 GenPept UniProtKB/Swiss-Prot:Q5R387

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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