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UGP UDP-glucose pyrophosphorylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39065, updated on 9-Dec-2024

Summary

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Official Symbol
UGPprovided by FlyBase
Official Full Name
UDP-glucose pyrophosphorylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0035978
Locus tag
Dmel_CG4347
See related
AllianceGenome:FB:FBgn0035978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4347; Dmel\CG4347; dUGP; UDPGPP; UGPase
Summary
Enables UTP:glucose-1-phosphate uridylyltransferase activity. Involved in UDP-glucose metabolic process and response to hyperoxia. Located in cytosol. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; germline cell; and larval somatic muscle cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See UGP in Genome Data Viewer
Location:
67B1-67B2; 3-29 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9350867..9358935, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9343967..9352035, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Peptidoglycan recognition protein LA Neighboring gene Peptidoglycan recognition protein LC Neighboring gene Peptidoglycan recognition protein LF Neighboring gene uncharacterized protein Neighboring gene small VCP interacting protein Neighboring gene Pyridoxal kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity. Yu Q, et al. Biochem J, 2012 Mar 1. PMID 22132858
  2. Coordinated movement, neuromuscular synaptogenesis and trans-synaptic signaling defects in Drosophila galactosemia models. Jumbo-Lucioni PP, et al. Hum Mol Genet, 2016 Sep 1. PMID 27466186, Free PMC Article
  3. The Drosophila NR4A nuclear receptor DHR38 regulates carbohydrate metabolism and glycogen storage. Ruaud AF, et al. Mol Endocrinol, 2011 Jan. PMID 21084378, Free PMC Article
  4. Review: Hypoxic and oxidative stress resistance in Drosophila melanogaster. Zhao HW, et al. Placenta, 2011 Mar. PMID 21353099, Free PMC Article
  5. How to eliminate pathogen without killing oneself? Immunometabolism of encapsulation and melanization in Drosophila. Dolezal T. Front Immunol, 2023. PMID 38124757, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UTP:glucose-1-phosphate uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UTP:glucose-1-phosphate uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UTP:glucose-1-phosphate uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UTP:glucose-1-phosphate uridylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in UDP-alpha-D-glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-alpha-D-glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-alpha-D-glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP-alpha-D-glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hyperoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
UDP-glucose pyrophosphorylase
Names
CG4347-PA
CG4347-PC
CG4347-PD
CG4347-PE
UGP-PA
UGP-PC
UGP-PD
UGP-PE
UTP-G-1-P uridyiyltransferase
uridine diphosphate-glucose pyrophosphorylase
NP_001163399.1
NP_001163400.1
NP_648300.3
NP_729469.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9350867..9358935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169929.2 → NP_001163400.1  UDP-glucose pyrophosphorylase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163400.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JI91, E8NH18
    Conserved Domains (1) summary
    pfam01704
    Location:68 → 483
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

  2. NM_140043.5 → NP_648300.3  UDP-glucose pyrophosphorylase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648300.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH18, Q8T0B8, Q9VSW1
    Conserved Domains (1) summary
    pfam01704
    Location:68 → 485
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

  3. NM_001169928.2 → NP_001163399.1  UDP-glucose pyrophosphorylase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163399.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5XCL5, E8NH18
    Conserved Domains (1) summary
    pfam01704
    Location:61 → 476
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

  4. NM_168325.4 → NP_729469.2  UDP-glucose pyrophosphorylase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729469.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH18, Q86NQ8, Q9VSW2
    Conserved Domains (1) summary
    pfam01704
    Location:61 → 478
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5XCL5 A5XCL5
E1JI91 E1JI91
Q8SXQ2 Q8SXQ2
Q9VSW1 Q9VSW1
Q9VSW2 Q9VSW2

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