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CG5989 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38984, updated on 9-Dec-2024

Summary

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Official Symbol
CG5989provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0017429
Locus tag
Dmel_CG5989
See related
AllianceGenome:FB:FBgn0017429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-66Db; Dmel\CG5989
Summary
Predicted to enable potassium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; longitudinal visceral muscle fiber; and visceral mesoderm derivative. Orthologous to human LETMD1 (LETM1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG5989 in Genome Data Viewer
Location:
66D8-66D8; 3-26 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8602411..8604149, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8595511..8597249, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein L14 Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila ribosomal protein L14-encoding gene, identified by a novel Minute mutation in a dense cluster of previously undescribed genes in cytogenetic region 66D. Saebøe-Larssen S, et al. Mol Gen Genet, 1997 Jun. PMID 9236770
  2. Conservation of gene order, structure and sequence between three closely linked genes in Drosophila melanogaster and Drosophila virilis. Lyamouri M, et al. Gene, 2002 Jan 9. PMID 11814692
  3. Selection on codon usage in Drosophila americana. Maside X, et al. Curr Biol, 2004 Jan 20. PMID 14738738
  4. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article
  5. Unraveling the Genetic Basis for the Rapid Diversification of Male Genitalia between Drosophila Species. Hagen JFD, et al. Mol Biol Evol, 2021 Jan 23. PMID 32931587, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables potassium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5989-PA
CG5989-PB
CG5989-PC
SAM methionine methyltransferase
anonymous-66Db

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8602411..8604149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274665.1 → NP_001261594.1  uncharacterized protein Dmel_CG5989, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261594.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF10, P91617
    Conserved Domains (1) summary
    pfam07766
    Location:139 → 392
    LETM1; LETM1-like protein

  2. NM_001274664.1 → NP_001261593.1  uncharacterized protein Dmel_CG5989, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261593.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEJ9, P91617
    Conserved Domains (1) summary
    pfam07766
    Location:148 → 401
    LETM1; LETM1-like protein

  3. NM_139985.4 → NP_648242.1  uncharacterized protein Dmel_CG5989, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91617, Q9VSM4
    Related
    FBpp0076373
    Conserved Domains (1) summary
    pfam07766
    Location:150 → 403
    LETM1; LETM1-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEJ9 M9PEJ9
M9PF10 M9PF10
P91616 P91616
P91617 P91617
Q9VSM4 Q9VSM4

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