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Jon66Cii Jonah 66Cii [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38953, updated on 9-Dec-2024

Summary

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Official Symbol
Jon66Ciiprovided by FlyBase
Official Full Name
Jonah 66Ciiprovided by FlyBase
Primary source
FLYBASE:FBgn0035887
Locus tag
Dmel_CG7170
See related
AllianceGenome:FB:FBgn0035887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
66C; CCG7170; CG7170; Dmel\CG7170; Jon66C; Jon66CII; SP165
Summary
Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Jon66Cii in Genome Data Viewer
Location:
66C10-66C10; 3-24 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8392820..8393649, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8385920..8386749, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ecdysone-inducible gene E1 Neighboring gene Jonah 66Ci Neighboring gene uncharacterized protein Neighboring gene monkey king protein Neighboring gene tRNA 2'-phosphotransferase Neighboring gene uncharacterized protein Neighboring gene Outer segment 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure-function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth. Nikolopoulos N, et al. Elife, 2023 Apr 12. PMID 37042660, Free PMC Article
  2. A bacteria-regulated gut peptide determines host dependence on specific bacteria to support host juvenile development and survival. Lee J, et al. BMC Biol, 2022 Nov 17. PMID 36397042, Free PMC Article
  3. Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion. Erkosar B, et al. Cell Host Microbe, 2015 Oct 14. PMID 26439865, Free PMC Article
  4. The detection of Jonah gene transcripts in Drosophila by in situ hybridization. Akam ME, et al. EMBO J, 1985 Jan. PMID 2410252, Free PMC Article
  5. D-Alanylation of teichoic acids contributes to Lactobacillus plantarum-mediated Drosophila growth during chronic undernutrition. Matos RC, et al. Nat Microbiol, 2017 Dec. PMID 28993620, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
jonah 66Cii
Names
CG7170-PA
Jon66Cii-PA
chymotrypsin-type peptidase
jonah 66C
NP_648217.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8392820..8393649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139960.2 → NP_648217.1  jonah 66Cii [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648217.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSJ2, R9TD69
    Related
    FBpp0076389
    Conserved Domains (2) summary
    smart00020
    Location:39 → 253
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:40 → 256
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U142 Q5U142
Q9VSJ2 Q9VSJ2

Gene LinkOut

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