ZNF662 zinc finger protein 662 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF662provided by HGNC
Official Full Name: zinc finger protein 662provided by HGNC
Primary source: HGNC:HGNC:31930
See related: Ensembl:ENSG00000182983 AllianceGenome:HGNC:31930
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in skin (RPKM 4.3), endometrium (RPKM 3.7) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 3p22.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (42906142..42919334)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (42921723..42934975)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (42947634..42960826)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

D15S1477 (e-PCR)
- UniSTS:474482

D11S3114 (e-PCR)
- UniSTS:152207

Potential readthrough

Included genes: ACKR2, GASK1A, KRBOX1

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 662

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134656.2 → NP_001128128.1 zinc finger protein 662 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longer isoform (2).

Source sequence(s)

AC092043, AK090754, AW117418, BC128085

Consensus CDS

CCDS46807.1

UniProtKB/Swiss-Prot

Q6ZS27

Related

ENSP00000329264.6, ENST00000328199.6

Conserved Domains (5) summary

smart00349
Location:33 → 92

KRAB; krueppel associated box

COG5048
Location:272 → 427

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:276 → 296

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:33 → 72

KRAB; KRAB box

pfam13465
Location:316 → 341

zf-H2C2_2; Zinc-finger double domain
NM_207404.4 → NP_997287.2 zinc finger protein 662 isoform 1

See identical proteins and their annotated locations for NP_997287.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate 5' exon, uses an alternate in-frame splice junction at the 5' end of an exon, and contains an alternate in-frame exon compared to variant 2. The resulting isoform (1) is shorter at the N-terminus, contains a single alternate aa, and contains an alternate segment compared to isoform 2.

Source sequence(s)

AC092043, AK090754, AK127779

Consensus CDS

CCDS2708.1

UniProtKB/Swiss-Prot

A1A4T9, F8W7S8, Q6ZNF8, Q6ZQW8, Q6ZS27

Related

ENSP00000405047.2, ENST00000440367.7

Conserved Domains (3) summary

COG5048
Location:246 → 401

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:250 → 270

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:290 → 315

zf-H2C2_2; Zinc-finger double domain