ldbr lariat debranching enzyme [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ldbrprovided by FlyBase
Official Full Name: lariat debranching enzymeprovided by FlyBase
Primary source: FLYBASE:FBgn0035838
Locus tag: Dmel_CG7942
See related: AllianceGenome:FB:FBgn0035838
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7942; Dmel\CG7942; Lbdr; Ldbr
Summary: Predicted to enable RNA lariat debranching enzyme activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human DBR1 (debranching RNA lariats 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8121827..8123615)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8114927..8116715)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA lariat debranching enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA lariat debranching enzyme activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA processing	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in RNA splicing, via transesterification reactions	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

NP_996022.1

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The following sections contain reference sequences that belong to a specific genome build. Explain