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Nulp1 Nuclear localized protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38897, updated on 4-Jan-2025

Summary

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Official Symbol
Nulp1provided by FlyBase
Official Full Name
Nuclear localized protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0027549
Locus tag
Dmel_CG7927
See related
AllianceGenome:FB:FBgn0027549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0172774.138; BcDNA:GH11023; CG7927; Dmel\CG7927; dNulp1; TCF25
Summary
Predicted to enable DNA-binding transcription factor activity. Involved in positive regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be part of RQC complex. Is expressed in adult head and organism. Orthologous to human TCF25 (transcription factor 25). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Nulp1 in Genome Data Viewer
Location:
66B6-66B6; 3-22 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8110368..8113406)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8103468..8106506)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sterile alpha and Armadillo motif Neighboring gene uncharacterized protein Neighboring gene mir-2501 stem loop Neighboring gene farinelli Neighboring gene Actin-related protein 3 Neighboring gene moleskin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The bHLH Protein Nulp1 is Essential for Femur Development Via Acting as a Cofactor in Wnt Signaling in Drosophila. Zeng Q, et al. Curr Mol Med, 2018 Mar 9. PMID 29437009, Free PMC Article
  2. MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Flynt AS, et al. Mol Cell, 2010 Jun 25. PMID 20620959, Free PMC Article
  3. Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans. Chung WJ, et al. Genome Res, 2011 Feb. PMID 21177960, Free PMC Article
  4. The Extracellular and Cytoplasmic Domains of Syndecan Cooperate Postsynaptically to Promote Synapse Growth at the Drosophila Neuromuscular Junction. Nguyen MU, et al. PLoS One, 2016. PMID 26987116, Free PMC Article
  5. ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD. Park J, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34551427, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RQC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nuclear localized protein 1
Names
CG7927-PA
CG7927-PB
CG7927-PC
Nulp1-PA
Nulp1-PB
Nulp1-PC
nuclear localized protein-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8110368..8113406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274629.1 → NP_001261558.1  nuclear localized protein 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261558.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSD4, Q9Y109
    Conserved Domains (1) summary
    pfam04910
    Location:236 → 567
    Tcf25; Transcriptional repressor TCF25

  2. NM_001274628.1 → NP_001261557.1  nuclear localized protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261557.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBV6
    Conserved Domains (1) summary
    pfam04910
    Location:236 → 567
    Tcf25; Transcriptional repressor TCF25

  3. NM_139917.3 → NP_648174.3  nuclear localized protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648174.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSD4, Q9Y109
    Related
    FBpp0076407
    Conserved Domains (1) summary
    pfam04910
    Location:236 → 567
    Tcf25; Transcriptional repressor TCF25
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBV6 M9PBV6
Q9Y109 Q9Y109

Gene LinkOut

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