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Sarm Sterile alpha and Armadillo motif [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38895, updated on 9-Dec-2024

Summary

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Official Symbol
Sarmprovided by FlyBase
Official Full Name
Sterile alpha and Armadillo motifprovided by FlyBase
Primary source
FLYBASE:FBgn0262579
Locus tag
Dmel_CG43119
See related
AllianceGenome:FB:FBgn0262579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.272; CG13680; CG13681; CG34373; CG43119; CG7905; CG7915; circRNA Edis; circ_1705; circ_Ect4; Dmel\CG43119; dsarm; dSarm; dSARM; dSarm1; dSARM1; ect4; Ect4; ECT4; Ect4/SARM; Edis; sarm; SARM; SARM1
Old locus tag
CG13680; CG7915; Dmel_CG13680; Dmel_CG13681; Dmel_CG34373; Dmel_CG7915
Summary
Enables NAD+ nucleosidase activity and STAT family protein binding activity. Involved in several processes, including NAD catabolic process; antiviral innate immune response; and positive regulation of receptor signaling pathway via STAT. Located in cytosol; neuron projection; and neuronal cell body. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and head epidermis primordium. Used to study neurodegenerative disease. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Sarm in Genome Data Viewer
Location:
66B4-66B6; 3-22 cM
Exon count:
21
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8063874..8108897)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8056974..8101997)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Leucine-CAG 1-3 Neighboring gene transfer RNA:Leucine-CAG 1-4 Neighboring gene transfer RNA:Leucine-CAG 1-5 Neighboring gene transfer RNA:Leucine-CAG 1-6 Neighboring gene transfer RNA:Leucine-CAG 1-7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43974 Neighboring gene uncharacterized protein Neighboring gene mir-2501 stem loop Neighboring gene Nuclear localized protein 1 Neighboring gene farinelli

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens. Gonzalez MA, et al. Biology (Basel), 2012 Dec 5. PMID 24832518, Free PMC Article
  2. Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing. Gu W, et al. Acta Crystallogr F Struct Biol Commun, 2021 Oct 1. PMID 34605441, Free PMC Article
  3. Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity. Sur M, et al. Cell Death Discov, 2018. PMID 30564462, Free PMC Article
  4. Axon Degeneration: Which Method to Choose? Coleman MP. Methods Mol Biol, 2020. PMID 32524468
  5. The circular RNA Edis regulates neurodevelopment and innate immunity. Xiong XP, et al. PLoS Genet, 2022 Oct. PMID 36301822, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early loss of endogenous NAD[+] following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition.
    Title: Early loss of endogenous NAD(+) following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition.
  2. Drosophila Ectoderm-expressed 4 modulates JAK/STAT pathway and protects flies against Drosophila C virus infection.
    Title: Drosophila Ectoderm-expressed 4 modulates JAK/STAT pathway and protects flies against Drosophila C virus infection.
  3. Injury-Induced Inhibition of Bystander Neurons Requires dSarm and Signaling from Glia.
    Title: Injury-Induced Inhibition of Bystander Neurons Requires dSarm and Signaling from Glia.
  4. In Ect4 knockdown flies Drosophila C virus-induced mortality occurred more quickly and virus accumulation was increased.
    Title: Drosophila miR-956 suppression modulates Ectoderm-expressed 4 and inhibits viral replication.
  5. findings show that loss of dSarm (sterile alpha/Armadillo/Toll-Interleukin receptor homology domain protein) cell-autonomously suppresses Wallerian degeneration for weeks after axotomy; results provide direct evidence that axons actively promote their own destruction after injury
    Title: dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables STAT family protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of MyD88-independent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of receptor signaling pathway via STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to axon injury IEA
Inferred from Electronic Annotation
more info
  
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sterile alpha and armadillo motif
Names
CG43119-PD
CG43119-PE
CG43119-PF
CG43119-PG
CG43119-PH
CG43119-PI
CG43119-PJ
CG43119-PK
CG43119-PL
CG43119-PM
Ect4
Ect4-derived immune suppressor
Ectoderm-expressed 4
SARM1
Sarm-PD
Sarm-PE
Sarm-PF
Sarm-PG
Sarm-PH
Sarm-PI
Sarm-PJ
Sarm-PK
Sarm-PL
Sarm-PM
drosophila sterile alpha and armadillo motif
sterile alpha, ARM, and TIR domain protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8063874..8108897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259733.1 → NP_001246662.1  sterile alpha and armadillo motif, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246662.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NE45
    Conserved Domains (4) summary
    cd09501
    Location:1031 → 1099
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:1100 → 1169
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:1031 → 1096
    SAM; Sterile alpha motif
    pfam13676
    Location:1185 → 1285
    TIR_2; TIR domain

  2. NM_001274627.1 → NP_001261556.1  sterile alpha and armadillo motif, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261556.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHR5
    Conserved Domains (4) summary
    cd09501
    Location:1031 → 1099
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:1100 → 1169
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:1031 → 1096
    SAM; Sterile alpha motif
    pfam13676
    Location:1185 → 1285
    TIR_2; TIR domain

  3. NM_001104071.2 → NP_001097541.1  sterile alpha and armadillo motif, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097541.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNN1
    Conserved Domains (4) summary
    cd09501
    Location:938 → 1006
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:1007 → 1076
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:938 → 1003
    SAM; Sterile alpha motif
    pfam13676
    Location:1092 → 1192
    TIR_2; TIR domain

  4. NM_001104074.3 → NP_001097544.1  sterile alpha and armadillo motif, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNN2
    Conserved Domains (4) summary
    cd09501
    Location:863 → 931
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:932 → 1001
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:863 → 928
    SAM; Sterile alpha motif
    pfam13676
    Location:1017 → 1117
    TIR_2; TIR domain

  5. NM_001104075.2 → NP_001097545.1  sterile alpha and armadillo motif, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097545.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNN3
    Conserved Domains (4) summary
    cd09501
    Location:687 → 755
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:756 → 825
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:687 → 752
    SAM; Sterile alpha motif
    pfam13676
    Location:841 → 941
    TIR_2; TIR domain

  6. NM_001043129.3 → NP_001036594.1  sterile alpha and armadillo motif, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036594.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E8H1, Q6IDD9, Q7KUA2, Q8SY48, Q9VSD2
    Conserved Domains (4) summary
    cd09501
    Location:687 → 755
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:756 → 825
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:687 → 752
    SAM; Sterile alpha motif
    pfam13676
    Location:841 → 941
    TIR_2; TIR domain

  7. NM_001259734.1 → NP_001246663.1  sterile alpha and armadillo motif, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFP2
    Conserved Domains (4) summary
    cd09501
    Location:687 → 755
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:756 → 825
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:687 → 752
    SAM; Sterile alpha motif
    pfam13676
    Location:841 → 941
    TIR_2; TIR domain

  8. NM_001382096.1 → NP_001369041.1  sterile alpha and armadillo motif, isoform L [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q7S1
    Conserved Domains (3) summary
    cd09501
    Location:505 → 573
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:574 → 643
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00255
    Location:658 → 795
    TIR; Toll - interleukin 1 - resistance

  9. NM_168254.2 → NP_729327.1  sterile alpha and armadillo motif, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729327.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6IDD9
    Related
    FBpp0293531
    Conserved Domains (4) summary
    cd09501
    Location:661 → 729
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:730 → 799
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:661 → 726
    SAM; Sterile alpha motif
    pfam13676
    Location:815 → 915
    TIR_2; TIR domain

  10. NM_001426711.1 → NP_001413639.1  sterile alpha and armadillo motif, isoform M [Drosophila melanogaster]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6M3Q7S1 A0A6M3Q7S1
A8JNN1 A8JNN1
A8JNN2 A8JNN2
A8JNN3 A8JNN3
M9NE45 M9NE45
M9NFP2 M9NFP2
M9PHR5 M9PHR5
Q6IDD9.1 Q6IDD9

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