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Clk - Clock

Enables DNA binding activity; chromatin binding activity; and protein heterodimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including circadian regulation of heart rate; locomotor rhythm; and regulation of gene expression. Part of CLOCK-BMAL transcription complex. Is expressed in several structures, including Bolwig nerve; adult fat body; brain; intrinsic neurons; and pacemaker neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease and alcohol use disorder. Orthologous to human CLOCK (clock circadian regulator) and NPAS2 (neuronal PAS domain protein 2). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa