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Ank2 Ankyrin 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38863, updated on 4-Jan-2025

Summary

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Official Symbol
Ank2provided by FlyBase
Official Full Name
Ankyrin 2provided by FlyBase
Primary source
FLYBASE:FBgn0261788
Locus tag
Dmel_CG42734
See related
AllianceGenome:FB:FBgn0261788
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ank2; ank2-L; CG18025; CG18227; CG18768; CG32373; CG32375; CG32377; CG34121; CG34158; CG34416; CG42734; CG7462; CG7493; dank2; Dank2; DAnk2; Dmel\CG42734; ESTS:149B10S; sp2523; SP2523
Old locus tag
CG32375; CG34121; CG34158; CG7462; Dmel_CG32375; Dmel_CG32377; Dmel_CG34121; Dmel_CG34158; Dmel_CG34416; Dmel_CG7462
Summary
Involved in several processes, including negative regulation of neuromuscular synaptic transmission; positive regulation of synaptic assembly at neuromuscular junction; and short-term memory. Located in neuromuscular junction; presynaptic periactive zone; and terminal bouton. Is expressed in several structures, including ganglia; nerve; neuromuscular junction; presumptive embryonic/larval system; and sensory neurons. Used to study Alzheimer's disease; epilepsy; and intellectual disability. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ank2 in Genome Data Viewer
Location:
66A8-66A10; 3-21 cM
Exon count:
26
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7655389..7718395, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7648489..7711495, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SD Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Medium-chain acyl-CoA dehydrogenase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Ankyrin Repeat Domain Controls Presynaptic Localization of Drosophila Ankyrin2 and Is Essential for Synaptic Stability. Weber T, et al. Front Cell Dev Biol, 2019. PMID 31475145, Free PMC Article
  2. Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration in Drosophila. Wodrich APK, et al. Biol Open, 2024 Jul 15. PMID 38912559, Free PMC Article
  3. The axonal localization of large Drosophila ankyrin2 protein isoforms is essential for neuronal functionality. Hortsch M, et al. Mol Cell Neurosci, 2002 May. PMID 12056839
  4. Control of axonal sprouting and dendrite branching by the Nrg-Ank complex at the neuron-glia interface. Yamamoto M, et al. Curr Biol, 2006 Aug 22. PMID 16920632
  5. Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila. Schwartz S, et al. Mol Brain, 2023 May 16. PMID 37194019, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila.
    Title: Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila.
  2. Expression of a portion of the C-terminal tail of the Ank2-L isoform of Ankyrin severely shortens the axon initial segment in Drosophila mushroom body (MB) neurons.
    Title: Expression of a Fragment of Ankyrin 2 Disrupts the Structure of the Axon Initial Segment and Causes Axonal Degeneration in Drosophila.
  3. We found that ddaE neurons have an axonal diffusion barrier proximal to the cell body that requires a giant isoform of the neuronal ankyrin Ank2. Furthermore, the potassium channel shal concentrates in the proximal axon in an Ank2-dependent manner
    Title: Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment.
  4. The heterotrimeric G protein Go functions as a transducer of Wingless-Frizzled 2 signaling in the synapse and Ankyrin 2 as a target of Go signaling required for neuromuscular junction formation
    Title: Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton.
  5. Ankyrin2 as a key presynaptic target of CK2.
    Title: Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2.
  6. Drosophila ankyrin 2 is required for synaptic stability.
    Title: Drosophila ankyrin 2 is required for synaptic stability.
  7. presynaptic Ank2-L lattice links synaptic membrane proteins and spectrin to the underlying microtubule cytoskeleton to organize and stabilize the presynaptic terminal.
    Title: A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in short-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic periactive zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ankyrin 2
Names
Ank2-PAA
Ank2-PAB
Ank2-PAC
Ank2-PE
Ank2-PF
Ank2-PG
Ank2-PJ
Ank2-PK
Ank2-PL
Ank2-PM
Ank2-PN
Ank2-PP
Ank2-PQ
Ank2-PR
Ank2-PS
Ank2-PT
Ank2-PU
Ank2-PV
Ank2-PW
Ank2-PX
Ank2-PY
Ank2-PZ
Ankyrin2 extra large
CG42734-PAA
CG42734-PAB
CG42734-PAC
CG42734-PE
CG42734-PF
CG42734-PG
CG42734-PJ
CG42734-PK
CG42734-PL
CG42734-PM
CG42734-PN
CG42734-PP
CG42734-PQ
CG42734-PR
CG42734-PS
CG42734-PT
CG42734-PU
CG42734-PV
CG42734-PW
CG42734-PX
CG42734-PY
CG42734-PZ
Dank2
SP2523
ankyrin2
ankyrin2-XL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7655389..7718395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300042.1 → NP_001286971.1  ankyrin 2, isoform Z [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286971.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JC49
    Conserved Domains (8) summary
    smart00218
    Location:1077 → 1180
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:514 → 639
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05403
    Location:23 → 158
    Plasmodium_HRP; Plasmodium histidine-rich protein (HRPII/III)
    pfam14755
    Location:2610 → 2687
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1567 → 1647
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:458 → 549
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:553 → 606
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:552 → 583
    ANK; ANK repeat [structural motif]

  2. NM_001274606.1 → NP_001261535.1  ankyrin 2, isoform V [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261535.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEN3
    Conserved Domains (8) summary
    smart00218
    Location:1077 → 1180
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:514 → 639
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05403
    Location:23 → 158
    Plasmodium_HRP; Plasmodium histidine-rich protein (HRPII/III)
    pfam14755
    Location:2750 → 2827
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1567 → 1647
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:458 → 549
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:553 → 606
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:552 → 583
    ANK; ANK repeat [structural motif]

  3. NM_001414102.1 → NP_001401034.1  ankyrin 2, isoform AC [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A9F2H0Y5

  4. NM_001104069.3 → NP_001097539.1  ankyrin 2, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097539.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNM5
    Conserved Domains (8) summary
    smart00218
    Location:1108 → 1211
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:514 → 639
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05403
    Location:23 → 158
    Plasmodium_HRP; Plasmodium histidine-rich protein (HRPII/III)
    pfam14755
    Location:2641 → 2718
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1598 → 1678
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:458 → 549
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:553 → 606
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:552 → 583
    ANK; ANK repeat [structural motif]

  5. NM_001202136.2 → NP_001189065.1  ankyrin 2, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189065.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRS5
    Conserved Domains (8) summary
    smart00218
    Location:1108 → 1211
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:514 → 639
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05403
    Location:23 → 158
    Plasmodium_HRP; Plasmodium histidine-rich protein (HRPII/III)
    pfam14755
    Location:2873 → 2950
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1598 → 1678
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:458 → 549
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:553 → 606
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:552 → 583
    ANK; ANK repeat [structural motif]

  6. NM_001202140.1 → NP_001189069.1  ankyrin 2, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189069.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MS19
    Conserved Domains (7) summary
    smart00218
    Location:934 → 1037
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:371 → 496
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam14755
    Location:2607 → 2684
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1424 → 1504
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:315 → 406
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:410 → 463
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]

  7. NM_001202138.1 → NP_001189067.1  ankyrin 2, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189067.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MSK6
    Conserved Domains (7) summary
    smart00218
    Location:965 → 1068
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:371 → 496
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam14755
    Location:2729 → 2806
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1455 → 1535
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:315 → 406
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:410 → 463
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]

  8. NM_001414101.1 → NP_001401033.1  ankyrin 2, isoform AB [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A9F2H0Y4

  9. NM_168227.4 → NP_729285.3  ankyrin 2, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729285.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KU92
    Conserved Domains (7) summary
    smart00218
    Location:927 → 1030
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam14755
    Location:2460 → 2537
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1417 → 1497
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  10. NM_001104066.2 → NP_001097536.1  ankyrin 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097536.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNM4
    Conserved Domains (6) summary
    smart00218
    Location:927 → 1030
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1417 → 1497
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  11. NM_001104068.2 → NP_001097538.1  ankyrin 2, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097538.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNM6
    Conserved Domains (7) summary
    smart00218
    Location:927 → 1030
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam14755
    Location:2566 → 2643
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1417 → 1497
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  12. NM_001300041.1 → NP_001286970.1  ankyrin 2, isoform Y [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286970.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JGD3
    Conserved Domains (6) summary
    smart00218
    Location:927 → 1030
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1417 → 1497
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  13. NM_001202139.1 → NP_001189068.1  ankyrin 2, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRR4
    Conserved Domains (7) summary
    smart00218
    Location:927 → 1030
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam14755
    Location:2600 → 2677
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1417 → 1497
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  14. NM_001202135.1 → NP_001189064.1  ankyrin 2, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189064.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRX1
    Conserved Domains (7) summary
    smart00218
    Location:927 → 1030
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam14755
    Location:2706 → 2783
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1417 → 1497
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  15. NM_001202141.1 → NP_001189070.1  ankyrin 2, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189070.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRX4
    Conserved Domains (7) summary
    smart00218
    Location:927 → 1030
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam14755
    Location:11936 → 12013
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1417 → 1497
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  16. NM_001300043.1 → NP_001286972.1  ankyrin 2, isoform AA [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286972.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCM1
    Conserved Domains (6) summary
    smart00218
    Location:927 → 1030
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1417 → 1497
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  17. NM_001104065.2 → NP_001097535.1  ankyrin 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097535.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNM7
    Conserved Domains (7) summary
    smart00218
    Location:958 → 1061
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam14755
    Location:2491 → 2568
    ER-remodelling; Intracellular membrane remodeller
    cd08317
    Location:1448 → 1528
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  18. NM_139891.4 → NP_648148.2  ankyrin 2, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648148.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KU95
    Conserved Domains (6) summary
    smart00218
    Location:927 → 1030
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1417 → 1497
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  19. NM_001274607.1 → NP_001261536.1  ankyrin 2, isoform W [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261536.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHP8
    Conserved Domains (5) summary
    smart00218
    Location:1077 → 1180
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:514 → 639
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:458 → 549
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:553 → 606
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:552 → 583
    ANK; ANK repeat [structural motif]

  20. NM_001104063.2 → NP_001097533.1  ankyrin 2, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097533.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NCP8
    Conserved Domains (5) summary
    smart00218
    Location:927 → 1030
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:209 → 300
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:403 → 456
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]

  21. NM_001104064.2 → NP_001097534.1  ankyrin 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097534.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3KN55
    Conserved Domains (4) summary
    cd00204
    Location:514 → 639
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:458 → 549
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:322 → 375
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:552 → 583
    ANK; ANK repeat [structural motif]

  22. NM_001274608.1 → NP_001261537.1  ankyrin 2, isoform X [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261537.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBV0
    Conserved Domains (4) summary
    cd00204
    Location:364 → 489
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:308 → 399
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:172 → 225
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNM4 A8JNM4
A8JNM5 A8JNM5
A8JNM6 A8JNM6
A8JNM7 A8JNM7
M9MRR4 M9MRR4
M9MRS5 M9MRS5
M9MRX1 M9MRX1
M9MRX4 M9MRX4
M9MS19 M9MS19
M9MSK6 M9MSK6
M9PBV0 M9PBV0
M9PEN3 M9PEN3
M9PHP8 M9PHP8
Q3KN55 Q3KN55
Q7KIS5 Q7KIS5
Q7KU92 Q7KU92
Q7KU95 Q7KU95
Q8SWY2 Q8SWY2
Q9I7Q8 Q9I7Q8
Q9NCP8 Q9NCP8
X2JC49 X2JC49
X2JCM1 X2JCM1
X2JGD3 X2JGD3

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