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tow target of wingless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38755, updated on 9-Dec-2024

Summary

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Official Symbol
towprovided by FlyBase
Official Full Name
target of winglessprovided by FlyBase
Primary source
FLYBASE:FBgn0035719
Locus tag
Dmel_CG14821
See related
AllianceGenome:FB:FBgn0035719
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14821; Dmel\CG14821; Tow
Summary
Involved in establishment of planar polarity; imaginal disc-derived wing hair organization; and negative regulation of smoothened signaling pathway. Located in nucleus. Is expressed in several structures, including adult head; ganglia; larval nervous system; and wing disc. Orthologous to human C1orf21 (chromosome 1 open reading frame 21). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See tow in Genome Data Viewer
Location:
65D3-65D3; 3-18 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6942856..6949313)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6935956..6942413)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45414 Neighboring gene long non-coding RNA:CR45412 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase complex assembly factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates. Sela N, et al. Genome Biol, 2010. PMID 20525173, Free PMC Article
  2. Spatiotemporally modulated Vestigial gradient by Wingless signaling adaptively regulates cell division for precise wing size control. Zhu H. J Theor Biol, 2011 Jan 7. PMID 20932848
  3. Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila. Ayers KL, et al. Dev Biol, 2009 May 15. PMID 19285058
  4. The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. Chung S, et al. Genetics, 2007 Jun. PMID 17409077, Free PMC Article
  5. An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. Sotillos S, et al. Dev Biol, 2010 Apr 15. PMID 20171201, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies indicate that negative regulation of the Vestigial gradient by Wingless signaling makes vestigial expression precise and robust.
    Title: Spatiotemporally modulated Vestigial gradient by Wingless signaling adaptively regulates cell division for precise wing size control.
  2. results demonstrate that Tow is an important novel regulator of the Hh pathway in the wing imaginal disc, and may shed light on the mechanism of Ptc repression of Smo
    Title: Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila.
  3. Target of Wingless (tow) acts downstream of Fz/Dsh and plays a role in restricting the number of hairs that wing cells form.
    Title: The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in establishment of planar polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in imaginal disc-derived wing hair organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
target of wingless
Names
CG14821-PC
CG14821-PD
CG14821-PE
CG14821-PF
CG14821-PG
tow-PC
tow-PD
tow-PE
tow-PF
tow-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6942856..6949313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274559.1 → NP_001261488.1  target of wingless, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261488.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNM0
    Conserved Domains (1) summary
    pfam15389
    Location:2 → 116
    DUF4612; Domain of unknown function (DUF4612)

  2. NM_001274561.1 → NP_001261490.1  target of wingless, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261490.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEJ7
    Conserved Domains (1) summary
    pfam15389
    Location:2 → 111
    DUF4612; Domain of unknown function (DUF4612)

  3. NM_001274560.1 → NP_001261489.1  target of wingless, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261489.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PET2
    Conserved Domains (1) summary
    pfam15389
    Location:2 → 116
    DUF4612; Domain of unknown function (DUF4612)

  4. NM_139804.2 → NP_648061.2  target of wingless, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648061.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VRZ4
    Conserved Domains (1) summary
    pfam15389
    Location:2 → 111
    DUF4612; Domain of unknown function (DUF4612)

  5. NM_001104056.2 → NP_001097526.1  target of wingless, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097526.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNM0
    Conserved Domains (1) summary
    pfam15389
    Location:2 → 116
    DUF4612; Domain of unknown function (DUF4612)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNM0 A8JNM0
M9PEJ7 M9PEJ7
M9PET2 M9PET2
Q7JWR6 Q7JWR6
Q9VRZ4 Q9VRZ4

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