cwf19l1 CWF19 like cell cycle control factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cwf19l1provided by ZNC
Official Full Name: CWF19 like cell cycle control factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-031204-5
See related: Ensembl:ENSDARG00000002128 AllianceGenome:ZFIN:ZDB-GENE-031204-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb1004; zgc:153338; si:ch211-234f20.6
Summary: Predicted to enable RNA lariat debranching enzyme activator activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Is expressed in blood. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 17. Orthologous to human CWF19L1 (CWF19 like cell cycle control factor 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (17642731..17653566)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (17647320..17664590)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA lariat debranching enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of post-mRNA release spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CWF19-like protein 1

Names: CWF19-like 1, cell cycle control

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044758.1 → NP_001038223.1 CWF19-like protein 1

See identical proteins and their annotated locations for NP_001038223.1

Status: PROVISIONAL

Source sequence(s)

BX890572

UniProtKB/Swiss-Prot

Q0P469, Q5RGJ5

UniProtKB/TrEMBL

B3DJ28

Related

ENSDARP00000010750.8, ENSDART00000026509.9

Conserved Domains (3) summary

cd07380
Location:9 → 230

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:453 → 540

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:325 → 431

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...