p2rx4b purinergic receptor P2X, ligand-gated ion channel, 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: p2rx4bprovided by ZNC
Official Full Name: purinergic receptor P2X, ligand-gated ion channel, 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030319-4
See related: Ensembl:ENSDARG00000042452 AllianceGenome:ZFIN:ZDB-GENE-030319-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: p2rx4.2; p2xr4.2
Summary: Enables extracellularly ATP-gated monoatomic cation channel activity. Acts upstream of or within excitatory postsynaptic potential and monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human P2RX4 (purinergic receptor P2X 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (30747564..30756618)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (30736582..30747386)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crystal structures of the zebrafish P2X(4) receptor in its closed, resting state
Title: Crystal structure of the ATP-gated P2X(4) ion channel in the closed state.

Submit: New GeneRIF Correction

General gene information

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Markers

fi27d12.x1 (e-PCR)
- UniSTS:197154

AI478014 (e-PCR)
- UniSTS:206415

fc79a06.y1 (e-PCR)
- UniSTS:194537

fb50c09.x1 (e-PCR)
- UniSTS:203250

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables extracellularly ATP-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ATP	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: P2X purinoceptor 4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198987.2 → NP_945338.2 P2X purinoceptor 4b

See identical proteins and their annotated locations for NP_945338.2

Status: VALIDATED

Source sequence(s)

BC162774

UniProtKB/TrEMBL

B3DHI3

Related

ENSDARP00000089746.3, ENSDART00000098975.5

Conserved Domains (1) summary

pfam00864
Location:12 → 380

P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

30747564..30756618

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021478206.2 → XP_021333881.1 P2X purinoceptor 4b isoform X1

UniProtKB/TrEMBL

A0A8M9QDM4

Conserved Domains (1) summary

pfam00864
Location:12 → 384

P2X_receptor; ATP P2X receptor