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Mir125a microRNA 125a [ Mus musculus (house mouse) ]

Gene ID: 387235, updated on 2-Nov-2024

Summary

Official Symbol
Mir125aprovided by MGI
Official Full Name
microRNA 125aprovided by MGI
Primary source
MGI:MGI:2676809
See related
Ensembl:ENSMUSG00000065479 miRBase:MI0000151; AllianceGenome:MGI:2676809
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mirn125a
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See Mir125a in Genome Data Viewer
Location:
17 A3.2; 17 10.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (18051074..18051141)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (17830812..17830879)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene sperm acrosome associated 6 Neighboring gene microRNA let7e Neighboring gene STARR-seq mESC enhancer starr_41967 Neighboring gene microRNA 99b Neighboring gene STARR-seq mESC enhancer starr_41968 Neighboring gene hyaluronan synthase 1 Neighboring gene predicted gene, 36907 Neighboring gene formyl peptide receptor 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Other Names

  • mmu-mir-125a

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of stem cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of stem cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029539.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC165361
    Related
    ENSMUST00000083545.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    18051074..18051141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)