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Sf3b6 Splicing factor 3b subunit 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38720, updated on 4-Jan-2025

Summary

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Official Symbol
Sf3b6provided by FlyBase
Official Full Name
Splicing factor 3b subunit 6provided by FlyBase
Primary source
FLYBASE:FBgn0035692
Locus tag
Dmel_CG13298
See related
AllianceGenome:FB:FBgn0035692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg13298; CG13298; Dmel\CG13298; SF3B6
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and somatic trunk mesoderm derivative. Orthologous to human SF3B6 (splicing factor 3b subunit 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Sf3b6 in Genome Data Viewer
Location:
65A8-65A8; 3-16 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6192124..6193179, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6185224..6186279, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene D19A Neighboring gene uncharacterized protein Neighboring gene Transportin Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Border cell polarity and collective migration require the spliceosome component Cactin. Miao G, et al. J Cell Biol, 2022 Jul 4. PMID 35612426, Free PMC Article
  2. Defining gene networks controlling the maintenance and function of the differentiation niche by an in vivo systematic RNAi screen. Gao Y, et al. J Genet Genomics, 2019 Jan 20. PMID 30745214
  3. The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing. Stegeman R, et al. J Mol Biol, 2016 Sep 11. PMID 27185460, Free PMC Article
  4. Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. Jankovics F, et al. PLoS One, 2014. PMID 24896584, Free PMC Article
  5. The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting. Liang D, et al. Mol Cell, 2017 Dec 7. PMID 29174924, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
splicing factor 3b subunit 6
Names
CG13298-PA
Sf3b6-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6192124..6193179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139780.3 → NP_648037.1  splicing factor 3b subunit 6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648037.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VRV7
    UniProtKB/TrEMBL
    A0A1B2AK42
    Related
    FBpp0076723
    Conserved Domains (1) summary
    cd12241
    Location:13 → 89
    RRM_SF3B14; RNA recognition motif (RRM) found in pre-mRNA branch site protein p14 (SF3B14) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRV7.1 Q9VRV7

Gene LinkOut

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Chemical Information
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