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Prdm13 PR/SET domain 13 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38713, updated on 4-Jan-2025

Summary

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Official Symbol
Prdm13provided by FlyBase
Official Full Name
PR/SET domain 13provided by FlyBase
Primary source
FLYBASE:FBgn0035687
Locus tag
Dmel_CG13296
See related
AllianceGenome:FB:FBgn0035687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13296; Dmel\CG13296; PRDM13
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; embryonic stomatogastric nervous system; ganglia; stomatogastric nervous system primordium; and ventral nerve cord primordium. Used to study North Carolina macular dystrophy. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human PRDM13 (PR/SET domain 13). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Prdm13 in Genome Data Viewer
Location:
65A7-65A7; 3-16 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6163127..6164682)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6156227..6157782)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45744 Neighboring gene Cuticular protein 65Az Neighboring gene fiery mountain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel duplication of PRMD13 causes North Carolina macular dystrophy: overexpression of PRDM13 orthologue in drosophila eye reproduces the human phenotype. Manes G, et al. Hum Mol Genet, 2017 Nov 15. PMID 28973654
  2. Rapid and efficient cDNA library screening by self-ligation of inverse PCR products (SLIP). Hoskins RA, et al. Nucleic Acids Res, 2005 Dec 2. PMID 16326860, Free PMC Article
  3. The genetic architecture of odor-guided behavior in Drosophila melanogaster. Anholt RR, et al. Behav Genet, 2001 Jan. PMID 11529271
  4. Generation of a versatile BiFC ORFeome library for analyzing protein-protein interactions in live Drosophila. Bischof J, et al. Elife, 2018 Sep 24. PMID 30247122, Free PMC Article
  5. Transcriptional regulators form diverse groups with context-dependent regulatory functions. Stampfel G, et al. Nature, 2015 Dec 3. PMID 26550828

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
PR/SET domain 13
Names
CG13296-PA
Prdm13-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6163127..6164682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139775.2 → NP_648032.1  PR/SET domain 13 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648032.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VRV0
    Related
    FBpp0076705
    Conserved Domains (4) summary
    COG5048
    Location:280 → 380
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:323 → 343
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:406 → 427
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:336 → 358
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRV0 Q9VRV0

Gene LinkOut

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