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l(3)mbn lethal (3) malignant blood neoplasm [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38701, updated on 9-Dec-2024

Summary

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Official Symbol
l(3)mbnprovided by FlyBase
Official Full Name
lethal (3) malignant blood neoplasmprovided by FlyBase
Primary source
FLYBASE:FBgn0002440
Locus tag
Dmel_CG12755
See related
AllianceGenome:FB:FBgn0002440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12755; Dmel\CG12755; l(3)malignant blood neoplasm1; l(3)mbn-1; l(3)mbn1; MBN
Summary
Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in plasma membrane. Predicted to be active in chitin-based extracellular matrix. Is expressed in several structures, including adult head; embryonic/larval plasmatocyte; larval digestive system; proplasmatocyte; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See l(3)mbn in Genome Data Viewer
Location:
65A6-65A6; 3-16 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6123934..6128807, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6117034..6121907, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene logjam Neighboring gene Ets at 65A Neighboring gene long non-coding RNA:CR46001 Neighboring gene antisense RNA:CR46005 Neighboring gene Larval cuticle protein Neighboring gene Cuticular protein 65Au

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A rapid rosetting method for separation of hemocyte sub-populations of Drosophila melanogaster. Vilmos P, et al. Dev Comp Immunol, 2004 May 17. PMID 15177109
  2. In vivo immunostaining of hemocyte compartments in Drosophila for live imaging. Csordás G, et al. PLoS One, 2014. PMID 24892745, Free PMC Article
  3. A Novel Method for Primary Blood Cell Culturing and Selection in Drosophila melanogaster. Kúthy-Sutus E, et al. Cells, 2022 Dec 21. PMID 36611818, Free PMC Article
  4. Immunoprofiling of Drosophila Hemocytes by Single-cell Mass Cytometry. Balog JÁ, et al. Genomics Proteomics Bioinformatics, 2021 Apr. PMID 33713850, Free PMC Article
  5. Cloning, structure, cellular localization, and possible function of the tumor suppressor gene lethal(3)malignant blood neoplasm-1 of Drosophila melanogaster. Konrad L, et al. Dev Biol, 1994 May. PMID 8174791

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of chitin-based larval cuticle IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of chitin-based larval cuticle ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in chitin-based cuticle development ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chitin-based extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chitin-based extracellular matrix ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
lethal (3) malignant blood neoplasm
Names
CG12755-PB
CG12755-PD
CG12755-PE
l(3)mbn-PB
l(3)mbn-PD
l(3)mbn-PE
lethal(3)malignant blood neoplasm-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6123934..6128807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316466.1 → NP_001303395.1  lethal (3) malignant blood neoplasm, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0WGW8
    Conserved Domains (1) summary
    pfam00379
    Location:31 → 77
    Chitin_bind_4; Insect cuticle protein

  2. NM_001316467.1 → NP_001303396.1  lethal (3) malignant blood neoplasm, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0WNZ2
    Conserved Domains (1) summary
    pfam00379
    Location:31 → 77
    Chitin_bind_4; Insect cuticle protein

  3. NM_168157.2 → NP_729143.2  lethal (3) malignant blood neoplasm, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729143.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52302, Q59E19, Q8MS87, Q9VRU6
    Related
    FBpp0076770
    Conserved Domains (1) summary
    pfam00379
    Location:31 → 77
    Chitin_bind_4; Insect cuticle protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WGW8 A0A0S0WGW8
A0A0S0WNZ2 A0A0S0WNZ2
P52302.2 P52302

Gene LinkOut

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