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CG42269 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38689, updated on 9-Dec-2024

Summary

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Official Symbol
CG42269provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0259164
Locus tag
Dmel_CG42269
See related
AllianceGenome:FB:FBgn0259164
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6596; CG6600; Dmel\CG42269
Old locus tag
Dmel_CG6596; Dmel_CG6600
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to several human genes including SLC22A1 (solute carrier family 22 member 1); SLC22A2 (solute carrier family 22 member 2); and SLC22A23 (solute carrier family 22 member 23). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG42269 in Genome Data Viewer
Location:
65A5-65A5; 3-16 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6066296..6071545)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6059396..6064645)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45441 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Independent effects of cis- and trans-regulatory variation on gene expression in Drosophila melanogaster. Wittkopp PJ, et al. Genetics, 2008 Mar. PMID 18245838, Free PMC Article
  2. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Eraly SA, et al. Physiol Genomics, 2004 Jun 17. PMID 15054140
  3. Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. Engelhart DC, et al. Int J Mol Sci, 2020 Mar 15. PMID 32183456, Free PMC Article
  4. Evolutionary changes in cis and trans gene regulation. Wittkopp PJ, et al. Nature, 2004 Jul 1. PMID 15229602
  5. Seizure suppression by gain-of-function escargot mutations. Hekmat-Scafe DS, et al. Genetics, 2005 Mar. PMID 15654097, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42269-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6066296..6071545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139762.3 → NP_648019.2  uncharacterized protein Dmel_CG42269 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648019.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VRT4
    Conserved Domains (2) summary
    cd06174
    Location:206 → 545
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:80 → 552
    2A0119; cation transport protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRT4 Q9VRT4

Gene LinkOut

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