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Rcc1 Regulator of chromosome condensation 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38669, updated on 4-Jan-2025

Summary

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Official Symbol
Rcc1provided by FlyBase
Official Full Name
Regulator of chromosome condensation 1provided by FlyBase
Primary source
FLYBASE:FBgn0002638
Locus tag
Dmel_CG10480
See related
AllianceGenome:FB:FBgn0002638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bj1; Bj1; BJ1; CG10480; CG18640 (Bj1); Dmel\CG10480; dRCC1; inxs; RanGEF; RCC1; sdt
Summary
Enables chromatin binding activity. Involved in several processes, including NLS-bearing protein import into nucleus; regulation of neurogenesis; and regulation of nucleocytoplasmic transport. Located in condensed chromosome and nucleus. Is expressed in several structures, including CNS glial cell; female germline cell; ganglia; head epidermis primordium; and neuroblasts. Orthologous to human RCC1 (regulator of chromosome condensation 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Rcc1 in Genome Data Viewer
Location:
65A1-65A1; 3-16 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5930262..5932773, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5923362..5925873, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene EGFR adaptor protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1. Frasch M. EMBO J, 1991 May. PMID 2022188, Free PMC Article
  2. Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S.cerevisiae. Ohtsubo M, et al. EMBO J, 1991 May. PMID 2022190, Free PMC Article
  3. RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles. Dasso M. Trends Biochem Sci, 1993 Mar. PMID 8480369
  4. The RanGEF Bj1 promotes prospero nuclear export and neuroblast self-renewal. Joy T, et al. Dev Neurobiol, 2015 May. PMID 25312250, Free PMC Article
  5. Altered nuclear transport and the most selfish of genes. Hawley RS. Dev Cell, 2001 Sep. PMID 11702939

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the Bj1 RanGEF promotes Prospero nuclear export and neuroblast self-renewal
    Title: The RanGEF Bj1 promotes prospero nuclear export and neuroblast self-renewal.
  2. crystal structure of a complex of Drosophila RCC1 and the nucleosome core particle at 2.9 A resolution, providing an atomic view of how a chromatin protein interacts with the histone and DNA components of the nucleosome
    Title: Structure of RCC1 chromatin factor bound to the nucleosome core particle.
  3. Data show that dRCC1 is required for nuclear import of nuclear localization signal sequence (NLS)-carrying cargo molecules and for cell proliferation and/or survival during germline, eye and wing development and that dRCC1 appears to facilitate apoptosis.
    Title: The Drosophila RCC1 homolog, Bj1, regulates nucleocytoplasmic transport and neural differentiation during Drosophila development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral cord development HMP PubMed 
Component Evidence Code Pubs
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
regulator of chromosome condensation 1
Names
Bj1 protein
CG10480-PA
CG10480-PB
CG10480-PC
Rcc1-PA
Rcc1-PB
Rcc1-PC
in excess
regulator of chromosome condensation 1 ortholog
side-out

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5930262..5932773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079219.3 → NP_523943.1  regulator of chromosome condensation 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523943.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1J1, P25171, Q9VRR5
    Related
    FBpp0076782
    Conserved Domains (2) summary
    pfam00415
    Location:363 → 414
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:131 → 158
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

  2. NM_168152.3 → NP_729119.1  regulator of chromosome condensation 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729119.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1J1, P25171, Q9VRR5
    Related
    FBpp0076784
    Conserved Domains (2) summary
    pfam00415
    Location:363 → 414
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:131 → 158
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

  3. NM_168151.3 → NP_729118.1  regulator of chromosome condensation 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729118.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1J1, P25171, Q9VRR5
    Related
    FBpp0076783
    Conserved Domains (2) summary
    pfam00415
    Location:363 → 414
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:131 → 158
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25171.2 P25171

Gene LinkOut

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