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QC Glutaminyl cyclase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38663, updated on 9-Dec-2024

Summary

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Official Symbol
QCprovided by FlyBase
Official Full Name
Glutaminyl cyclaseprovided by FlyBase
Primary source
FLYBASE:FBgn0052412
Locus tag
Dmel_CG32412
See related
AllianceGenome:FB:FBgn0052412
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10487; CG32412; Dmel\CG32412; DromeQC
Summary
Enables glutaminyl-peptide cyclotransferase activity. Located in extracellular region. Is expressed in adult head; embryonic hypopharynx; and organism. Orthologous to human QPCTL (glutaminyl-peptide cyclotransferase like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
64F4-64F5; 3-15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5900835..5902456, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5893935..5895556, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon subunit 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4. Kolenko P, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Apr 1. PMID 23545638, Free PMC Article
  2. Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers. Seifert F, et al. Bioorg Chem, 2015 Jun. PMID 25981125
  3. Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs. Koch B, et al. Biochemistry, 2012 Sep 18. PMID 22897232
  4. Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization. Schilling S, et al. Biochemistry, 2007 Sep 25. PMID 17722885
  5. The microevolutionary response to male-limited X-chromosome evolution in Drosophila melanogaster reflects macroevolutionary patterns. Abbott JK, et al. J Evol Biol, 2020 Jun. PMID 32176391

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inorganic phosphate and glutaminyl cyclases catalyze N-terminal pyroglutamate formation.
    Title: Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers.
  2. glutaminyl cyclase crystallized in space group I4, with unit-cell parameters a = b = 122.3, c = 72.7 A
    Title: Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4.
  3. Drosophila's glutaminyl cyclases primary structures suggest different subcellular localizations. DromeQC(CG32412)appeared to be secreted due to N-term signal peptide, isoDromeQC (CG5976) contains either N-term mitochondrial targeting or secretion signal.
    Title: Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutaminyl-peptide cyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminyl-peptide cyclotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutaminyl-peptide cyclotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutaminyl cyclase
Names
CG32412-PA
QC-PA
NP_729109.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5900835..5902456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168145.3 → NP_729109.1  glutaminyl cyclase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729109.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VRQ9
    Related
    FBpp0076788
    Conserved Domains (1) summary
    cd03880
    Location:36 → 325
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRQ9.2 Q9VRQ9

Gene LinkOut

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