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CG13287 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38660, updated on 9-Dec-2024

Summary

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Official Symbol
CG13287provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035643
Locus tag
Dmel_CG13287
See related
AllianceGenome:FB:FBgn0035643
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG13287
Summary
Predicted to enable chromatin binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in central brain primordium; dorsal head epidermis anlage in statu nascendi; embryonic brain; larval ventral nerve cord; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 10. Orthologous to human PRDM8 (PR/SET domain 8) and ZNF488 (zinc finger protein 488). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG13287 in Genome Data Viewer
Location:
64F3-64F3; 3-15 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5882304..5884090)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5875404..5877190)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene vein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA polymerase epsilon subunit 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spliceosome malfunction causes neurodevelopmental disorders with overlapping features. Li D, et al. J Clin Invest, 2024 Jan 2. PMID 37962958, Free PMC Article
  2. Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors. Hannon CE, et al. Elife, 2024 Jan 26. PMID 38275292, Free PMC Article
  3. Rapid and efficient cDNA library screening by self-ligation of inverse PCR products (SLIP). Hoskins RA, et al. Nucleic Acids Res, 2005 Dec 2. PMID 16326860, Free PMC Article
  4. The genetic architecture of odor-guided behavior in Drosophila melanogaster. Anholt RR, et al. Behav Genet, 2001 Jan. PMID 11529271
  5. Identification of Drosophila Mutants Affecting Defense to an Entomopathogenic Fungus. Lu HL, et al. Sci Rep, 2015 Jul 23. PMID 26202798, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG13287-PA
CG13287-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5882304..5884090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139737.2 → NP_647994.1  uncharacterized protein Dmel_CG13287, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647994.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F9W340, Q9VRQ6
    Related
    FBpp0076735
    Conserved Domains (2) summary
    sd00017
    Location:360 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:363 → 418
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)

  2. NM_001274525.1 → NP_001261454.1  uncharacterized protein Dmel_CG13287, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261454.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F9W340, M9PEQ7
    Conserved Domains (2) summary
    sd00017
    Location:360 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:363 → 418
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEQ7 M9PEQ7
Q9VRQ6 Q9VRQ6

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