vn vein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: vnprovided by FlyBase
Official Full Name: veinprovided by FlyBase
Primary source: FLYBASE:FBgn0003984
Locus tag: Dmel_CG10491
See related: AllianceGenome:FB:FBgn0003984
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10491; CT29452; ddd; Dm vn; Dmel\CG10491; l(3)10567; l(3)10568; l(3)ddd; l(3)L6A; l(3)rF264; l(3)vn10567; P1749; Vein; Vn; wvn
Summary: Enables epidermal growth factor receptor binding activity; heparin binding activity; and receptor ligand activity. Involved in several processes, including leg disc proximal/distal pattern formation; nervous system development; and wing disc development. Located in extracellular space. Is expressed in several structures, including epithelium; germ layer; imaginal disc; organism subdivision; and visceral muscle cell. Human ortholog(s) of this gene implicated in several diseases, including cannabis dependence; cerebral malaria; cerebrovascular disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Orthologous to human NRG1 (neuregulin 1) and NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64E12-64F2; 3-15 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5813338..5845664, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5806438..5838764, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vein is the EGFR ligand in the air sac development and Vein promotes cell proliferation and survival during air sac development.
Title: FGF coordinates air sac development by activation of the EGF ligand Vein through the transcription factor PntP2.
Vein, produced by the wrapping glia, also regulates the formation of septate junctions in the abutting subperineurial glia.
Title: Axonal wrapping in the Drosophila PNS is controlled by glia-derived neuregulin homolog Vein.
Findings provide strong evidence that Msk signals non-autonomously through the Vein-Egfr signaling pathway for late tendon cell late differentiation and/or maintenance.
Title: Moleskin is essential for the formation of the myotendinous junction in Drosophila.
results show that the activity of Vn is controlled both positively and negatively, demonstrating the existence of additional levels at which Egfr signaling can be regulated
Title: Regulation of the Drosophila epidermal growth factor-ligand vein is mediated by multiple domains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERBB signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in R8 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in haltere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in leg disc proximal/distal pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in notum cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in notum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vein

Names: CG10491-PA; CG10491-PC; Dm vein; defective dorsal discs; vn-PA; vn-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

5813338..5845664 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014565.2 → NP_001014565.2 vein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014565.2

Status: REVIEWED

UniProtKB/TrEMBL

C4IXW6, Q59E20

Conserved Domains (2) summary

smart00408
Location:471 → 538

IGc2; Immunoglobulin C-2 Type

pfam00008
Location:566 → 598

EGF; EGF-like domain
NM_079218.3 → NP_523942.2 vein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523942.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94918, Q9VRQ3

UniProtKB/TrEMBL

C4IXW6

Related

FBpp0076790

Conserved Domains (2) summary

smart00408
Location:471 → 538

IGc2; Immunoglobulin C-2 Type

pfam00008
Location:566 → 598

EGF; EGF-like domain