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Myt1 Myt1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38649, updated on 9-Dec-2024

Summary

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Official Symbol
Myt1provided by FlyBase
Official Full Name
Myt1provided by FlyBase
Primary source
FLYBASE:FBgn0040298
Locus tag
Dmel_CG32417
See related
AllianceGenome:FB:FBgn0040298
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10569; CG32417; Dmel\CG32417; dMyt1; Dmyt1; Myt; MYT 1; myt1; MYT1
Summary
Enables protein serine/threonine/tyrosine kinase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; meiotic nuclear division; and spermatogenesis. Located in Golgi apparatus. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Myt1 in Genome Data Viewer
Location:
64E7-64E7; 3-15 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5777476..5779591, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5770576..5772691, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene scrawny Neighboring gene viriato Neighboring gene antisense RNA:CR45026 Neighboring gene Peptidoglycan recognition protein LD Neighboring gene Pmi Neighboring gene Cellular retinaldehyde binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila myt1 is the major cdk1 inhibitory kinase for wing imaginal disc development. Jin Z, et al. Genetics, 2008 Dec. PMID 18940789, Free PMC Article
  2. Identification of Drosophila Myt1 kinase and its role in Golgi during mitosis. Cornwell WD, et al. Cell Signal, 2002 May. PMID 11882391
  3. Aging and insulin signaling differentially control normal and tumorous germline stem cells. Kao SH, et al. Aging Cell, 2015 Feb. PMID 25470527, Free PMC Article
  4. Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning. Hunter GL, et al. Development, 2016 Jul 1. PMID 27226324, Free PMC Article
  5. Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells. Guo Y, et al. Biol Open, 2016 Nov 15. PMID 27737823, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myt1 Kinase Couples Mitotic Cell Cycle Exit with Differentiation in Drosophila.
    Title: Myt1 Kinase Couples Mitotic Cell Cycle Exit with Differentiation in Drosophila.
  2. dMyt1 serves Cdk1 regulatory functions that are important both for normal cell-cycle progression and for coordinating mitosis with critical developmental processes
    Title: Drosophila myt1 is the major cdk1 inhibitory kinase for wing imaginal disc development.
  3. Myt1 serves unique Cdk1 regulatory functions required for efficient coupling of cell differentiation with cell cycle progression.
    Title: Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived cystoblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell size IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatocyte division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogonial cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Myt1
Names
CG32417-PA
Myt1-PA
NP_647987.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5777476..5779591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139730.3 → NP_647987.2  Myt1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647987.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q961T4, Q9NI63, Q9VRP6
    Related
    FBpp0076824
    Conserved Domains (2) summary
    cd14050
    Location:100 → 349
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
    pfam00069
    Location:102 → 349
    Pkinase; Protein kinase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NI63.2 Q9NI63

Gene LinkOut

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