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shep alan shepard [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38605, updated on 4-Jan-2025

Summary

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Official Symbol
shepprovided by FlyBase
Official Full Name
alan shepardprovided by FlyBase
Primary source
FLYBASE:FBgn0052423
Locus tag
Dmel_CG32423
See related
AllianceGenome:FB:FBgn0052423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alan; alan-shepard; anon-EST:Posey83; anon-WO0118547.198; anon-WO0172774.41; BcDNA:LD40028; BcDNA:RH63980; CG10647; CG10649; cg10668; CG10668; CG32423; Dmel\CG32423; Shep
Summary
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Involved in several processes, including female courtship behavior; gravitaxis; and neuron remodeling. Located in cytosol. Is expressed in several structures, including circulatory system primordium; ganglia; glial cell; larval neurons; and somatic precursor cell. Orthologous to human RBMS1 (RNA binding motif single stranded interacting protein 1); RBMS2 (RNA binding motif single stranded interacting protein 2); and RBMS3 (RNA binding motif single stranded interacting protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See shep in Genome Data Viewer
Location:
64C7-64C11; 3-13 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5155821..5277944, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5148921..5271044, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Alanyl-tRNA synthetase, mitochondrial Neighboring gene Signal recognition particle 54k Neighboring gene XPG-like endonuclease Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45741 Neighboring gene long non-coding RNA:CR45742

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. metaseq: a Python package for integrative genome-wide analysis reveals relationships between chromatin insulators and associated nuclear mRNA. Dale RK, et al. Nucleic Acids Res, 2014 Aug. PMID 25063299, Free PMC Article
  2. The neurodevelopmental genes alan shepard and Neuroglian contribute to female mate preference in African Drosophila melanogaster. Roy PR, et al. J Evol Biol, 2024 Aug 1. PMID 38900077,
  3. Clustering of Drosophila housekeeping promoters facilitates their expression. Corrales M, et al. Genome Res, 2017 Jul. PMID 28420691, Free PMC Article
  4. Drosophila Shep and C. elegans SUP-26 are RNA-binding proteins that play diverse roles in nervous system development. Schachtner LT, et al. Dev Genes Evol, 2015 Nov. PMID 26271810
  5. Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling. Chen D, et al. Nat Commun, 2021 Nov 4. PMID 34737269, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA-binding capability of Shep is necessary to antagonize gypsy insulator activities and promote neuronal maturation.
    Title: Shep RNA-Binding Capacity Is Required for Antagonism of gypsy Chromatin Insulator Activity.
  2. results reveal direct regulation of transcriptional programs by Shep to regulate neuronal remodeling during metamorphosis.
    Title: Shep regulates Drosophila neuronal remodeling by controlling transcription of its chromatin targets.
  3. Data show that RNA binding proteins sup-26 and shep are required for the development of diverse cell types within the nematode and fly nervous systems during embryonic and larval stages.
    Title: Drosophila Shep and C. elegans SUP-26 are RNA-binding proteins that play diverse roles in nervous system development.
  4. Thus, shep regulates metamorphic growth of the bursicon neurons, and it may also serve as a general regulator of neuronal growth during metamorphic remodeling.
    Title: Neuronal remodeling during metamorphosis is regulated by the alan shepard (shep) gene in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gravitaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metamorphosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress HMP PubMed 
involved_in response to gravity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alan shepard
Names
CG32423-PA
CG32423-PB
CG32423-PD
CG32423-PE
CG32423-PF
CG32423-PG
CG32423-PH
CG32423-PI
shep-PA
shep-PB
shep-PD
shep-PE
shep-PF
shep-PG
shep-PH
shep-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5155821..5277944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168112.4 → NP_729055.1  alan shepard, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729055.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSV2
    Related
    FBpp0076877
    Conserved Domains (2) summary
    cd12243
    Location:136 → 204
    RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
    cd12244
    Location:224 → 302
    RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

  2. NM_001274510.1 → NP_001261439.1  alan shepard, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261439.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSV2
    Conserved Domains (2) summary
    cd12243
    Location:21 → 91
    RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
    cd12244
    Location:109 → 187
    RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

  3. NM_001259707.1 → NP_001246636.1  alan shepard, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246636.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JID7, M9ND50, M9PEP6, Q7KU60, Q86BS4, Q8MSV2, Q8SWY6, Q95S20, Q95S52, Q9VRK3, Q9VRK5
    Conserved Domains (2) summary
    cd12243
    Location:243 → 313
    RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
    cd12244
    Location:322 → 400
    RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

  4. NM_168114.5 → NP_729057.3  alan shepard, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729057.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSV2
    Conserved Domains (2) summary
    cd12243
    Location:21 → 91
    RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
    cd12244
    Location:109 → 187
    RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

  5. NM_168111.4 → NP_729054.3  alan shepard, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729054.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSV2
    Conserved Domains (2) summary
    cd12243
    Location:231 → 301
    RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
    cd12244
    Location:310 → 388
    RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

  6. NM_168113.3 → NP_729056.1  alan shepard, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729056.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSV2
    Related
    FBpp0076876
    Conserved Domains (2) summary
    cd12243
    Location:136 → 204
    RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
    cd12244
    Location:224 → 302
    RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

  7. NM_001274509.1 → NP_001261438.1  alan shepard, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261438.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSV2
    Conserved Domains (2) summary
    cd12243
    Location:21 → 91
    RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
    cd12244
    Location:111 → 189
    RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

  8. NM_001169879.2 → NP_001163350.1  alan shepard, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163350.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSV2
    Conserved Domains (2) summary
    cd12243
    Location:21 → 91
    RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
    cd12244
    Location:111 → 189
    RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MSV2.2 Q8MSV2

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