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Yod1 Yod1 deubiquitinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38603, updated on 4-Jan-2025

Summary

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Official Symbol
Yod1provided by FlyBase
Official Full Name
Yod1 deubiquitinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0035593
Locus tag
Dmel_CG4603
See related
AllianceGenome:FB:FBgn0035593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4603; Dmel\CG4603; dYOD1; Otu1; Q9VRJ9
Summary
Predicted to enable cysteine-type deubiquitinase activity. Involved in positive regulation of double-strand break repair. Orthologous to human YOD1 (YOD1 deubiquitinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Yod1 in Genome Data Viewer
Location:
64C7-64C7; 3-13 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5133871..5135670)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5126971..5128770)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45160 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Threonyl-carbamoyl synthesis 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila. Farkas A, et al. Sci Rep, 2023 Dec 11. PMID 38081944, Free PMC Article
  2. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Bingol B, et al. Nature, 2014 Jun 19. PMID 24896179
  3. Deubiquitylases from genes to organism. Clague MJ, et al. Physiol Rev, 2013 Jul. PMID 23899565
  4. Systematic analysis of the physiological importance of deubiquitinating enzymes. Tsou WL, et al. PLoS One, 2012. PMID 22937016, Free PMC Article
  5. Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster. Páhi ZG, et al. Sci Rep, 2022 Apr 7. PMID 35393473, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila.
    Title: The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Yod1 deubiquitinase
Names
CG4603-PA
CG4603-PB
CG4603-PC
Yod1-PA
Yod1-PB
Yod1-PC
NP_001261435.1
NP_001261436.1
NP_647951.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5133871..5135670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274507.1 → NP_001261436.1  Yod1 deubiquitinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261436.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T9H3, Q9VRJ9
    UniProtKB/TrEMBL
    B6IDQ5
    Conserved Domains (3) summary
    smart00213
    Location:5 → 80
    UBQ; Ubiquitin homologues
    COG5539
    Location:158 → 346
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    cl00155
    Location:10 → 80
    UBQ; Ubiquitin-like proteins

  2. NM_139694.4 → NP_647951.2  Yod1 deubiquitinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647951.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T9H3, Q9VRJ9
    UniProtKB/TrEMBL
    B6IDQ5
    Related
    FBpp0076867
    Conserved Domains (3) summary
    smart00213
    Location:5 → 80
    UBQ; Ubiquitin homologues
    COG5539
    Location:158 → 346
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    cl00155
    Location:10 → 80
    UBQ; Ubiquitin-like proteins

  3. NM_001274506.1 → NP_001261435.1  Yod1 deubiquitinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261435.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PED6
    Conserved Domains (3) summary
    smart00213
    Location:5 → 80
    UBQ; Ubiquitin homologues
    COG5539
    Location:158 → 346
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    cl00155
    Location:10 → 80
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B6IDQ5 B6IDQ5
M9PED6 M9PED6
Q9VRJ9.1 Q9VRJ9

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