AlaRS-m Alanyl-tRNA synthetase, mitochondrial [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: AlaRS-mprovided by FlyBase
Official Full Name: Alanyl-tRNA synthetase, mitochondrialprovided by FlyBase
Primary source: FLYBASE:FBgn0028962
Locus tag: Dmel_CG4633
See related: AllianceGenome:FB:FBgn0028962
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Aats-ala-m; AlaS; CG4633; Dm mt AlaRS; Dmel\CG4633
Summary: Predicted to enable alanine-tRNA ligase activity and aminoacyl-tRNA editing activity. Predicted to be involved in alanyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in adult head; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 8 and progressive leukoencephalopathy with ovarian failure. Orthologous to human AARS2 (alanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5146098..5149852)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5139198..5142952)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables alanine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alanine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables alanine-tRNA ligase activity	TAS Traceable Author Statement more info	PubMed
enables aminoacyl-tRNA editing activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminoacyl-tRNA editing activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in alanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in alanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in alanyl-tRNA aminoacylation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed

NP_523932.2

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The following sections contain reference sequences that belong to a specific genome build. Explain