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ATPsynCF6L ATP synthase, coupling factor 6-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38592, updated on 9-Dec-2024

Summary

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Official Symbol
ATPsynCF6Lprovided by FlyBase
Official Full Name
ATP synthase, coupling factor 6-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0035585
Locus tag
Dmel_CG12027
See related
AllianceGenome:FB:FBgn0035585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ATPR; CG12027; Dmel\CG12027
Summary
Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in ATP metabolic process. Predicted to be part of proton-transporting ATP synthase complex, coupling factor F(o). Is expressed in adult head and spermatozoon. Orthologous to human ATP5PF (ATP synthase peripheral stalk subunit F6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ATPsynCF6L in Genome Data Viewer
Location:
64C4-64C4; 3-13 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5011444..5012133, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5011444..5012133, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Connectin Neighboring gene long non-coding RNA:CR45685 Neighboring gene testis-specific gamma-tubulin ring protein 128 Neighboring gene long non-coding RNA:CR43884 Neighboring gene long non-coding RNA:CR46198

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Testis-specific ATP synthase peripheral stalk subunits required for tissue-specific mitochondrial morphogenesis in Drosophila. Sawyer EM, et al. BMC Cell Biol, 2017 Mar 23. PMID 28335714, Free PMC Article
  2. Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Gallach M, et al. Genome Biol Evol, 2010. PMID 21037198, Free PMC Article
  3. Loss of Drosophila Clueless differentially affects the mitochondrial proteome compared to loss of Sod2 and Pink1. Sen A, et al. Front Physiol, 2022. PMID 36388112, Free PMC Article
  4. Two functionally different mitochondrial phosphate carriers support Drosophila melanogaster OXPHOS throughout distinct developmental stages. Curcio R, et al. Biochim Biophys Acta Mol Cell Res, 2024 Jan. PMID 37898376
  5. Comparison of the oxidative phosphorylation (OXPHOS) nuclear genes in the genomes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae. Tripoli G, et al. Genome Biol, 2005. PMID 15693940, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
  
part_of proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ATP synthase, coupling factor 6-like
Names
ATP synthase coupling factor 6
ATPsynCF6L-PA
CG12027-PA
testis-enriched subunit F6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5011444..5012133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139685.2 → NP_647942.1  ATP synthase, coupling factor 6-like [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647942.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4QQ07, Q9VZ72
    Related
    FBpp0073228
    Conserved Domains (1) summary
    pfam05511
    Location:9 → 87
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZ72 Q9VZ72

Gene LinkOut

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