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Dhc64C - Dynein heavy chain 64C

Enables microtubule motor activity. Involved in several processes, including germ cell development; microtubule cytoskeleton organization; and nervous system development. Located in several cellular components, including axon cytoplasm; kinetochore; and posterior cell cortex. Part of dynein complex and ribonucleoprotein complex. Is expressed in adult head; adult heart; germline cell; and gonad. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant intellectual developmental disorder 13; and spinal muscular atrophy with lower extremity predominant 1. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa