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ens ensconsin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38491, updated on 4-Jan-2025

Summary

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Official Symbol
ensprovided by FlyBase
Official Full Name
ensconsinprovided by FlyBase
Primary source
FLYBASE:FBgn0264693
Locus tag
Dmel_CG14998
See related
AllianceGenome:FB:FBgn0264693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14998; Dm-308; Dmel\CG14998; Ens; ensc; swoosh
Summary
Enables microtubule binding activity. Involved in several processes, including larval somatic muscle development; microtubule cytoskeleton organization; and nuclear migration. Located in apical part of cell. Is expressed in adult head; oocyte; and organism. Orthologous to human MAP7D2 (MAP7 domain containing 2); MAP7D3 (MAP7 domain containing 3); and MAP7 (microtubule associated protein 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See ens in Genome Data Viewer
Location:
64A7-64A7; 3-10 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4122907..4134550, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4122907..4134550, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Activated Cdc42 kinase Neighboring gene Chd64 Neighboring gene Replication factor C subunit 4 Neighboring gene Ras opposite

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1. Barlan K, et al. Curr Biol, 2013 Feb 18. PMID 23394833, Free PMC Article
  2. Competition between microtubule-associated proteins directs motor transport. Monroy BY, et al. Nat Commun, 2018 Apr 16. PMID 29662074, Free PMC Article
  3. Deletion of endogenous Tau proteins is not detrimental in Drosophila. Burnouf S, et al. Sci Rep, 2016 Mar 15. PMID 26976084, Free PMC Article
  4. Drosophila Nesprin-1 controls glutamate receptor density at neuromuscular junctions. Morel V, et al. Cell Mol Life Sci, 2014 Sep. PMID 24492984, Free PMC Article
  5. Ensconsin-dependent changes in microtubule organization and LINC complex-dependent changes in nucleus-nucleus interactions result in quantitatively distinct myonuclear positioning defects. Collins MA, et al. Mol Biol Cell, 2021 Nov 1. PMID 34524872, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. At endogenous levels, Bsg25D positively regulates Ens activity during myonuclear positioning, but excess Bsg25D disrupts Ens localization and MT organization, with disastrous consequences for myonuclear positioning and muscle function.
    Title: The Drosophila Ninein homologue Bsg25D cooperates with Ensconsin in myonuclear positioning.
  2. Map7/7D1 and its Drosophila ortholog, Ensconsin show planar-polarized distribution in both mouse and fly epithelia, and Ensconsin influences proper localization of Drosophila Disheveled in pupal wing cells.
    Title: Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling.
  3. Ensconsin cooperates with its binding partner Kinesin-1 during interphase to trigger centrosome separation.
    Title: Ensconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells.
  4. Ensconsin is essential for vesicle transport by kinesin-1 in cultured Drosophila S2 cells and primary neurons. Microtubule-binding domain of ensconsin is not required for this activity.
    Title: The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1.
  5. our study suggests that ensconsin is an essential cofactor for all known functions of kinesin-1
    Title: The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1.
  6. identification of the microtubule-associated protein ensconsin (Ens)/microtubule-associated protein 7 (MAP7) and kinesin heavy chain (Khc)/Kif5b as essential, evolutionarily conserved regulators of myonuclear positioning in Drosophila and cultured mammalian myotubes
    Title: MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function.
  7. ensconsin promotes productive recruitment of Kinesin-1 to microtubules.
    Title: Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of microtubule-based movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ensconsin
Names
CG14998-PA
CG14998-PB
CG14998-PC
CG14998-PD
CG14998-PE
CG14998-PF
CG14998-PG
CG14998-PH
CG14998-PI
CG14998-PJ
CG14998-PK
CG14998-PL
enconsin
ens-PA
ens-PB
ens-PC
ens-PD
ens-PE
ens-PF
ens-PG
ens-PH
ens-PI
ens-PJ
ens-PK
ens-PL
swoosh

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4122907..4134550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300004.1 → NP_001286933.1  ensconsin, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286933.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW7, Q8IRC0
    Conserved Domains (3) summary
    PTZ00121
    Location:18 → 130
    PTZ00121; MAEBL; Provisional
    PRK07003
    Location:284 → 477
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
    pfam15927
    Location:581 → 620
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  2. NM_168062.3 → NP_728939.2  ensconsin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728939.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW7, Q8IRC0
    Conserved Domains (3) summary
    PTZ00121
    Location:18 → 130
    PTZ00121; MAEBL; Provisional
    PRK07003
    Location:284 → 477
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
    pfam15927
    Location:581 → 620
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  3. NM_139604.2 → NP_647861.2  ensconsin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647861.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW7, Q8IRC1
    Conserved Domains (2) summary
    PRK07003
    Location:219 → 412
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
    pfam15927
    Location:516 → 555
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  4. NM_001274474.1 → NP_001261403.1  ensconsin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261403.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW7, F2FB68
    Conserved Domains (2) summary
    PRK07003
    Location:234 → 427
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
    pfam15927
    Location:531 → 570
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  5. NM_001274473.1 → NP_001261402.1  ensconsin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261402.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW7, M9PBN6
    Conserved Domains (3) summary
    PTZ00121
    Location:16 → 127
    PTZ00121; MAEBL; Provisional
    PRK07003
    Location:354 → 547
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
    pfam15927
    Location:651 → 690
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  6. NM_001274471.1 → NP_001261400.1  ensconsin, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261400.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW7, M9PE93
    Conserved Domains (3) summary
    PTZ00121
    Location:18 → 128
    PTZ00121; MAEBL; Provisional
    PRK07003
    Location:401 → 594
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
    pfam15927
    Location:698 → 737
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  7. NM_001274470.1 → NP_001261399.1  ensconsin, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261399.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW7, M9PEK8
    Conserved Domains (2) summary
    PRK07003
    Location:319 → 512
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
    pfam15927
    Location:616 → 655
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  8. NM_001274472.1 → NP_001261401.1  ensconsin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261401.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHB1
    Conserved Domains (3) summary
    PTZ00121
    Location:16 → 127
    PTZ00121; MAEBL; Provisional
    PRK07003
    Location:486 → 679
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
    pfam15927
    Location:783 → 822
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  9. NM_168061.2 → NP_728938.2  ensconsin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728938.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW7, Q9VZI0
    Conserved Domains (2) summary
    PRK07003
    Location:237 → 430
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
    pfam15927
    Location:534 → 573
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  10. NM_168063.2 → NP_728940.2  ensconsin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728940.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW7, Q8IRB9
    Conserved Domains (1) summary
    pfam05672
    Location:662 → 802
    MAP7; MAP7 (E-MAP-115) family

  11. NM_168064.2 → NP_728941.2  ensconsin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728941.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW7, Q6NQY4, Q9I7T2
    Conserved Domains (2) summary
    PRK07003
    Location:273 → 466
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
    pfam15927
    Location:570 → 609
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  12. NM_001104028.2 → NP_001097498.1  ensconsin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097498.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNK1
    Conserved Domains (1) summary
    pfam05672
    Location:920 → 1060
    MAP7; MAP7 (E-MAP-115) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNK1 A8JNK1
F2FB68 F2FB68
M9PBN6 M9PBN6
M9PE93 M9PE93
M9PEK8 M9PEK8
M9PHB1 M9PHB1
Q8IRB9 Q8IRB9
Q8IRC0 Q8IRC0
Q8IRC1 Q8IRC1
Q9I7T2 Q9I7T2
Q9VZI0 Q9VZI0

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