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Mul1 Mitochondrial E3 ubiquitin protein ligase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38472, updated on 9-Dec-2024

Summary

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Official Symbol
Mul1provided by FlyBase
Official Full Name
Mitochondrial E3 ubiquitin protein ligase 1provided by FlyBase
Primary source
FLYBASE:FBgn0035483
Locus tag
Dmel_CG1134
See related
AllianceGenome:FB:FBgn0035483
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1134; Dmel\CG1134; mul1; MUL1
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in positive regulation of mitochondrial fission and protein ubiquitination. Predicted to be located in mitochondrial outer membrane and peroxisome. Is expressed in adult head; anlage in statu nascendi; hindgut anlage in statu nascendi; organism; and spermatozoon. Used to study Parkinson's disease. Orthologous to human MUL1 (mitochondrial E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Mul1 in Genome Data Viewer
Location:
64A4-64A4; 3-10 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4021457..4023501)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4021457..4023058)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Forkhead box L1 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 64a Neighboring gene Gustatory receptor 64c Neighboring gene Gustatory receptor 64b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models. Doktór B, et al. BMC Neurosci, 2019 May 28. PMID 31138137, Free PMC Article
  2. Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants. Zhang T, et al. Elife, 2017 Mar 21. PMID 28322724, Free PMC Article
  3. Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development. Hanlon CD, et al. Dev Biol, 2016 Nov 15. PMID 27618755, Free PMC Article
  4. FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo. Sanchez-Martinez A, et al. PLoS Biol, 2023 Aug. PMID 37535686, Free PMC Article
  5. PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions. Tsai PI, et al. Mol Cell, 2018 Mar 1. PMID 29456190

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. changes observed in the brains of these Drosophila models of Parkinson's Disease, in which mitochondrial ligases MUL1 and PARKIN do not function, may explain the mechanisms of some neurological and behavioural symptoms of PD.
    Title: Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models.
  2. MUL1 acts in parallel to the PINK1/parkin pathway on a shared target mitofusin to maintain mitochondrial integrity.
    Title: MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial E3 ubiquitin protein ligase 1
Names
CG1134-PA
CG1134-PB
Mul1-PA
Mul1-PB
mitochondrial E3 ubiquitin protein ligase 1 homologue

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4021457..4023501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316436.1 → NP_001303365.1  mitochondrial E3 ubiquitin protein ligase 1, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VZJ9
    Conserved Domains (3) summary
    pfam12483
    Location:89 → 243
    GIDE; E3 Ubiquitin ligase
    pfam13920
    Location:286 → 329
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cd16787
    Location:290 → 325
    mRING-HC-C3HC5_CGRF1; modified RING-HC finger (C3HC5-type) [structural motif]

  2. NM_139590.4 → NP_647847.1  mitochondrial E3 ubiquitin protein ligase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647847.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VZJ9
    Related
    FBpp0073049
    Conserved Domains (3) summary
    pfam12483
    Location:89 → 243
    GIDE; E3 Ubiquitin ligase
    pfam13920
    Location:286 → 329
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cd16787
    Location:290 → 325
    mRING-HC-C3HC5_CGRF1; modified RING-HC finger (C3HC5-type) [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZJ9.1 Q9VZJ9

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