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Sc2 Sc2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38457, updated on 4-Jan-2025

Summary

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Official Symbol
Sc2provided by FlyBase
Official Full Name
Sc2provided by FlyBase
Primary source
FLYBASE:FBgn0035471
Locus tag
Dmel_CG10849
See related
AllianceGenome:FB:FBgn0035471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10849; Dmel\CG10849; dSc2; l(3)05634; l(3)63Eb; l(3)SH4; SC2; Ter[CG10849]
Summary
Predicted to enable very-long-chain enoyl-CoA reductase activity. Predicted to be involved in very long-chain fatty acid biosynthetic process. Located in cytoplasm and endomembrane system. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 14 and catecholaminergic polymorphic ventricular tachycardia 3. Orthologous to several human genes including TECR (trans-2,3-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Sc2 in Genome Data Viewer
Location:
63F5-63F6; 3-9 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3903492..3905035)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3903492..3905035)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene Caffeine, calcium, zinc sensitivity 1 Neighboring gene Ubiquitin-63E Neighboring gene imaginal discs arrested Neighboring gene maggie

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotypic characterization of Drosophila ida mutants: defining the role of APC5 in cell cycle progression. Bentley AM, et al. J Cell Sci, 2002 Mar 1. PMID 11870214
  2. A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila. Patch K, et al. PLoS One, 2009 Oct 23. PMID 19862331, Free PMC Article
  3. Genetic analysis of the Drosophila 63F early puff. Characterization of mutations in E63-1 and maggie, a putative Tom22. Vaskova M, et al. Genetics, 2000 Sep. PMID 10978288, Free PMC Article
  4. Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. Chen H, et al. Hum Mol Genet, 2010 Feb 1. PMID 19933170
  5. A modifier screen in the eye reveals control genes for Krüppel activity in the Drosophila embryo. Carrera P, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724781, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain enoyl-CoA reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in endomembrane system HDA PubMed 

General protein information

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Preferred Names
Sc2
Names
CG10849-PA
Sc2-PA
Ubiquitin-63E
lethal(3)63Eb
NP_647836.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3903492..3905035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139579.3 → NP_647836.2  Sc2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647836.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6IDR5, Q9VZL3
    Related
    FBpp0073017
    Conserved Domains (3) summary
    cd01801
    Location:3 → 79
    Tsc13_N; Ubiquitin-like domain of Tsc13
    PLN02560
    Location:15 → 299
    PLN02560; enoyl-CoA reductase
    cl21511
    Location:150 → 302
    PEMT; Phospholipid methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95R45 Q95R45
Q9VZL3 Q9VZL3

Gene LinkOut

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