Gatc glutamyl-tRNA amidotransferase subunit C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gatcprovided by MGI
Official Full Name: glutamyl-tRNA amidotransferase subunit Cprovided by MGI
Primary source: MGI:MGI:1923776
See related: Ensembl:ENSMUSG00000029536 AllianceGenome:MGI:1923776
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010003O18Rik
Summary: Predicted to enable ATP binding activity and glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 42. Orthologous to human GATC (glutamyl-tRNA amidotransferase subunit C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 14.3), CNS E14 (RPKM 13.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.05 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115471301..115479220, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115333242..115341161, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutamyl-tRNA Gln amidotransferase subunit interference produces a strong defect in mitochondrial translation without affecting the stability of the newly synthesized proteins. .
Title: Glutamyl-tRNAGln amidotransferase is essential for mammalian mitochondrial translation in vivo.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutaminyl-tRNAGln biosynthesis via transamidation	IEA Inferred from Electronic Annotation more info
involved_in glutaminyl-tRNAGln biosynthesis via transamidation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial translation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational fidelity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of glutamyl-tRNA(Gln) amidotransferase complex	IEA Inferred from Electronic Annotation more info
part_of glutamyl-tRNA(Gln) amidotransferase complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

Names: gatC-like protein; glu-AdT subunit C; glutamyl-tRNA(Gln) amidotransferase, subunit C homolog

NP_083921.1

EC 6.3.5.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.