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Ids Iduronate 2-sulfatase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38423, updated on 4-Jan-2025

Summary

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Official Symbol
Idsprovided by FlyBase
Official Full Name
Iduronate 2-sulfataseprovided by FlyBase
Primary source
FLYBASE:FBgn0035445
Locus tag
Dmel_CG12014
See related
AllianceGenome:FB:FBgn0035445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey282; CG12014; Dmel\CG12014; IDS
Summary
Enables iduronate-2-sulfatase activity. Predicted to be involved in glycosaminoglycan catabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in mucopolysaccharidosis II. Orthologous to human IDS (iduronate 2-sulfatase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ids in Genome Data Viewer
Location:
63D2-63D2; 3-8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3378268..3380083)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3378268..3380083)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45737 Neighboring gene sprouty Neighboring gene mir-2282 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modeling Mucopolysaccharidosis Type II in the Fruit Fly by Using the RNA Interference Approach. Rigon L, et al. Life (Basel), 2020 Oct 30. PMID 33142967, Free PMC Article
  2. Comparative studies of vertebrate iduronate 2-sulfatase (IDS) genes and proteins: evolution of A mammalian X-linked gene. Holmes RS. 3 Biotech, 2017 May. PMID 28401457, Free PMC Article
  3. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. Yu M, et al. PLoS Genet, 2023 May. PMID 37200393, Free PMC Article
  4. The genetic basis and adult reproductive consequences of developmental thermal plasticity. Rodrigues LR, et al. J Anim Ecol, 2022 Jun. PMID 35060127, Free PMC Article
  5. Exploiting the Potential of Drosophila Models in Lysosomal Storage Disorders: Pathological Mechanisms and Drug Discovery. Rigon L, et al. Biomedicines, 2021 Mar 7. PMID 33800050, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables iduronate-2-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iduronate-2-sulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables iduronate-2-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycosaminoglycan catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
iduronate 2-sulfatase
Names
CG12014-PA
Ids-PA
NP_647814.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3378268..3380083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139557.2 → NP_647814.1  iduronate 2-sulfatase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647814.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJ62, Q9VZP8
    Related
    FBpp0072939
    Conserved Domains (2) summary
    COG3119
    Location:21 → 509
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16030
    Location:24 → 495
    iduronate-2-sulfatase; iduronate-2-sulfatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZP8 Q9VZP8

Gene LinkOut

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