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Ythdc1 YTH domain containing 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38420, updated on 9-Dec-2024

Summary

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Official Symbol
Ythdc1provided by FlyBase
Official Full Name
YTH domain containing 1provided by FlyBase
Primary source
FLYBASE:FBgn0027616
Locus tag
Dmel_CG12076
See related
AllianceGenome:FB:FBgn0027616
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH01918; CG12076; Dmel\CG12076; dYT521-B; YT521; YT521-B; ythdc; Ythdc
Summary
Enables N6-methyladenosine-containing RNA reader activity; mRNA binding activity; and pre-mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and sex determination. Located in nucleus. Is expressed in larval central nervous system and ventral neurectoderm. Orthologous to human YTHDC1 (YTH N6-methyladenosine RNA binding protein C1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ythdc1 in Genome Data Viewer
Location:
63D2-63D2; 3-8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3370451..3374170, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3370451..3374170, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene karst Neighboring gene Drosomycin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A neural m(6)A/Ythdf pathway is required for learning and memory in Drosophila. Kan L, et al. Nat Commun, 2021 Mar 5. PMID 33674589, Free PMC Article
  2. The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders. Angelova MT, et al. Front Bioeng Biotechnol, 2018. PMID 29707539, Free PMC Article
  3. Cell type-specific regulation of m(6) A modified RNAs in the aging Drosophila brain. Perlegos AE, et al. Aging Cell, 2024 Mar. PMID 38205931, Free PMC Article
  4. The RNA-binding protein Nab2 regulates levels of the RhoGEF Trio to govern axon and dendrite morphology. Lancaster CL, et al. Mol Biol Cell, 2024 Aug 1. PMID 38985523, Free PMC Article
  5. Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila. Worpenberg L, et al. EMBO J, 2021 Feb 15. PMID 33428246, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. m(6)A RNA methylation regulates promoter- proximal pausing of RNA polymerase II.
    Title: m(6)A RNA methylation regulates promoter- proximal pausing of RNA polymerase II.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N6-methyladenosine-containing RNA reader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N6-methyladenosine-containing RNA reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pre-mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sex determination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
YTH domain containing 1
Names
CG12076-PA
CG12076-PB
YT521-B
Ythdc1-PA
Ythdc1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3370451..3374170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139554.4 → NP_647811.2  YTH domain containing 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647811.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IH35, Q8IRD2, Q9VZQ1, Q9Y172
    Related
    FBpp0072940
    Conserved Domains (1) summary
    pfam04146
    Location:254 → 392
    YTH; YT521-B-like domain

  2. NM_168029.2 → NP_728876.1  YTH domain containing 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728876.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRD2
    Related
    FBpp0072941
    Conserved Domains (1) summary
    pfam04146
    Location:243 → 380
    YTH; YT521-B-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZQ1.2 Q9VZQ1

Gene LinkOut

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