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Gtpx Glutathione peroxidase homolog with thioredoxin peroxidase activity [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38413, updated on 9-Dec-2024

Summary

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Official Symbol
Gtpxprovided by FlyBase
Official Full Name
Glutathione peroxidase homolog with thioredoxin peroxidase activityprovided by FlyBase
Primary source
FLYBASE:FBgn0035438
Locus tag
Dmel_CG12013
See related
AllianceGenome:FB:FBgn0035438
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0257455.17; CG12013; dGPX4; Dmel\CG12013; DmGpx; DmGPx; DmPHGPx; Gpx; GPx; GTPx; Gtpx-1; GTPx-1; PGTPx; phgpx; phGpx; PHGPx; Tpx1
Summary
Enables thioredoxin-dependent peroxiredoxin activity. Involved in intestinal stem cell homeostasis; response to endoplasmic reticulum stress; and response to oxidative stress. Located in Golgi apparatus. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval fat body; and germline cell. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Gtpx in Genome Data Viewer
Location:
63D1-63D1; 3-8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3326265..3328626)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3326265..3328626)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class C Neighboring gene uncharacterized protein Neighboring gene Dolichyl-phosphate mannosyltransferase subunit 2 Neighboring gene Striatin interacting protein Neighboring gene long non-coding RNA:CR45380 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The catalytic site of glutathione peroxidases. Tosatto SC, et al. Antioxid Redox Signal, 2008 Sep. PMID 18500926
  2. Drosophila melanogaster "a potential model organism" for identification of pharmacological properties of plants/plant-derived components. Panchal K, et al. Biomed Pharmacother, 2017 May. PMID 28320100
  3. The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases. Maiorino M, et al. J Mol Biol, 2007 Jan 26. PMID 17098255
  4. N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression. Niraula P, et al. Biogerontology, 2019 Aug. PMID 31115735
  5. Loss of ferritin in developing wing cells: Apoptosis and ferroptosis coincide. Hernández-Gallardo AK, et al. PLoS Genet, 2020 Jan. PMID 31895941, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. e catalytic mechanism of DmGPx, unlike that of selenocysteine (Sec)GPxs, involves formation of an internal disulfide that is pivotal to the interaction with Trx
    Title: The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-dependent peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endomembrane system HDA PubMed 

General protein information

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Preferred Names
glutathione peroxidase homolog with thioredoxin peroxidase activity
Names
CG12013-PA
CG12013-PC
CG12013-PD
Gtpx-PA
Gtpx-PC
Gtpx-PD
PHGPx
PHGPx with glutathione peroxidase activity
glutathione peroxidase
glutathione peroxidase I
phospholipid hydroperoxide glutathione peroxidase
NP_728868.1
NP_728869.1
NP_728870.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3326265..3328626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168024.2 → NP_728868.1  glutathione peroxidase homolog with thioredoxin peroxidase activity, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRD4
    Related
    FBpp0072930
    Conserved Domains (1) summary
    cd00340
    Location:41 → 194
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

  2. NM_168025.2 → NP_728869.1  glutathione peroxidase homolog with thioredoxin peroxidase activity, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS7, Q8IRD3
    Related
    FBpp0072932
    Conserved Domains (1) summary
    cd00340
    Location:81 → 234
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

  3. NM_168026.2 → NP_728870.1  glutathione peroxidase homolog with thioredoxin peroxidase activity, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728870.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZQ8
    Related
    FBpp0072931
    Conserved Domains (1) summary
    cd00340
    Location:12 → 165
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IRD3 Q8IRD3
Q8IRD4 Q8IRD4
Q9VZQ8 Q9VZQ8

Gene LinkOut

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