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CG17746 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38400, updated on 9-Dec-2024

Summary

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Official Symbol
CG17746provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035425
Locus tag
Dmel_CG17746
See related
AllianceGenome:FB:FBgn0035425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cg17746; Dmel\CG17746; PP2C
Summary
Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol. Is expressed in adult head and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG17746 in Genome Data Viewer
Location:
63C1-63C1; 3-7 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3236805..3239578, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3236805..3239578, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1 Neighboring gene La-related protein 4B Neighboring gene long non-coding RNA:CR45424 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A phosphoswitch at acinus-serine(437) controls autophagic responses to cadmium exposure and neurodegenerative stress. Nandi N, et al. Elife, 2022 Jan 17. PMID 35037620, Free PMC Article
  2. Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling. Chen AS, et al. Cancer Res, 2019 Mar 15. PMID 30530503, Free PMC Article
  3. An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock. Agrawal P, et al. G3 (Bethesda), 2016 Dec 7. PMID 27784754, Free PMC Article
  4. Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microRNA. Vilmos P, et al. Genetics, 2013 Oct. PMID 23852386, Free PMC Article
  5. Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose. Ji Z, et al. Elife, 2021 Apr 13. PMID 33847264, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG17746-PA
CG17746-PB
protein phosphatase 2C
NP_647794.1
NP_728844.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3236805..3239578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168008.3 → NP_728844.1  uncharacterized protein Dmel_CG17746, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZS1
    Related
    FBpp0072956
    Conserved Domains (1) summary
    cd00143
    Location:22 → 284
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  2. NM_139537.4 → NP_647794.1  uncharacterized protein Dmel_CG17746, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647794.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZS1
    Related
    FBpp0072955
    Conserved Domains (1) summary
    cd00143
    Location:22 → 284
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZS1 Q9VZS1

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