U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hob hobbit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38395, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
hobprovided by FlyBase
Official Full Name
hobbitprovided by FlyBase
Primary source
FLYBASE:FBgn0035420
Locus tag
Dmel_CG14967
See related
AllianceGenome:FB:FBgn0035420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14967; Dmel\CG14967; sP2
Summary
Enables phosphatidylinositol binding activity. Located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Is expressed in adult head; organism; and spermatozoon. Orthologous to human BLTP2 (bridge-like lipid transfer protein family member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See hob in Genome Data Viewer
Location:
63B13-63B14; 3-6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3210992..3218920, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3210992..3218920, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene gryzun Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene neutral sphingomyelinase Neighboring gene Ribosomal protein L28

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Hob proteins: Putative, novel lipid transfer proteins at ER-PM contact sites. Neuman SD, et al. Contact (Thousand Oaks), 2021 Jan-Dec. PMID 36589899, Free PMC Article
  2. Hobbit regulates intracellular trafficking to drive insulin-dependent growth during Drosophila development. Neuman SD, et al. Development, 2018 Jun 11. PMID 29891564, Free PMC Article
  3. The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites. Neuman SD, et al. J Cell Sci, 2022 Mar 1. PMID 34415038, Free PMC Article
  4. Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance. Takechi H, et al. Elife, 2021 Mar 5. PMID 33666170, Free PMC Article
  5. Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microRNA. Vilmos P, et al. Genetics, 2013 Oct. PMID 23852386, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites.
    Title: The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of positive regulation of regulated secretory pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-plasma membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
hobbit
Names
CG14967-PB
CG14967-PC
hob-PB
hob-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3210992..3218920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139532.2 → NP_647789.2  hobbit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647789.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VZS7
    Conserved Domains (4) summary
    pfam10293
    Location:887 → 959
    DUF2405; Domain of unknown function (DUF2405)
    pfam10344
    Location:26 → 666
    Fmp27; Mitochondrial protein from FMP27
    pfam10347
    Location:1071 → 1203
    Fmp27_GFWDK; RNA pol II promoter Fmp27 protein domain
    pfam10351
    Location:1774 → 2239
    Apt1; Golgi-body localization protein domain

  2. NM_001316473.1 → NP_001303402.1  hobbit, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VZS7
    Conserved Domains (4) summary
    pfam10293
    Location:887 → 959
    DUF2405; Domain of unknown function (DUF2405)
    pfam10344
    Location:26 → 666
    Fmp27; Mitochondrial protein from FMP27
    pfam10347
    Location:1071 → 1203
    Fmp27_GFWDK; RNA pol II promoter Fmp27 protein domain
    pfam10351
    Location:1774 → 2239
    Apt1; Golgi-body localization protein domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MLX1 Q8MLX1
Q9VZS7.2 Q9VZS7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools