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MnM myomesin and myosin binding protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38384, updated on 9-Dec-2024

Summary

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Official Symbol
MnMprovided by FlyBase
Official Full Name
myomesin and myosin binding proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035410
Locus tag
Dmel_CG14964
See related
AllianceGenome:FB:FBgn0035410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14964; CT34810; Dmel\CG14964; dMnM
Summary
Involved in sarcomere organization. Predicted to be active in M band. Is expressed in adult head; adult heart; and adult somatic muscle cell. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); lethal congenital contracture syndrome 4; and muscle tissue disease (multiple). Orthologous to human MYBPC1 (myosin binding protein C1); MYBPC2 (myosin binding protein C2); and MYBPC3 (myosin binding protein C3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See MnM in Genome Data Viewer
Location:
63B9-63B9; 3-6 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3172817..3178580, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3172817..3178580, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene girdin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart. Auxerre-Plantié E, et al. Dis Model Mech, 2020 Dec 18. PMID 33033063, Free PMC Article
  2. Regular Exercise Rescues Heart Function Defects and Shortens the Lifespan of Drosophila Caused by dMnM Downregulation. Gu W, et al. Int J Environ Res Public Health, 2022 Dec 9. PMID 36554435, Free PMC Article
  3. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Lee JD, et al. Curr Biol, 2001 Jul 24. PMID 11509241
  4. Identifying susceptibility genes for primary ovarian insufficiency on the high-risk genetic background of a fragile X premutation. Trevino CE, et al. Fertil Steril, 2021 Sep. PMID 34016428, Free PMC Article
  5. Third Chromosome Balancer Inversions Disrupt Protein-Coding Genes and Influence Distal Recombination Events in Drosophila melanogaster. Miller DE, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172211, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
myomesin and myosin binding protein
Names
CG14964-PB
MnM-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3172817..3178580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139522.3 → NP_647779.2  myomesin and myosin binding protein [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647779.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZT8
    Conserved Domains (5) summary
    cd00096
    Location:155 → 224
    Ig; Immunoglobulin domain
    smart00410
    Location:243 → 323
    IG_like; Immunoglobulin like
    cd00063
    Location:327 → 411
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:138 → 227
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:250 → 323
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZT8 Q9VZT8

Gene LinkOut

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