ND-30 NADH dehydrogenase (ubiquinone) 30 kDa subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ND-30provided by FlyBase
Official Full Name: NADH dehydrogenase (ubiquinone) 30 kDa subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0266582
Locus tag: Dmel_CG12079
See related: AllianceGenome:FB:FBgn0266582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: C-I 30; C-I-NDUFS3; C-I30; CG 12079; CG12079; Dmel\CG12079; dNDUFS3; ND30; NDufS3; NDUFS3; NUGM
Summary: Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in reactive oxygen species metabolic process. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval somatic muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 8. Orthologous to human NDUFS3 (NADH:ubiquinone oxidoreductase core subunit S3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (3158485..3159578, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (3158485..3159578, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NADH dehydrogenase (ubiquinone) activity	IEA Inferred from Electronic Annotation more info
contributes_to NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IC Inferred by Curator more info	PubMed
involved_in reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IC Inferred by Curator more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

Names: 30 kDa subunit of complex-I; CG12079-PA; NADH dehydrogenase (ubiquinone) Fe-S protein 3; NADH ubiquinone oxidoreductase 30 kDa; NADH-UBIQUINONE OXIDOREDUCTASE 30 KDA SUBUNIT; NADH:ubiquinone oxidoreductase 30 kDa subunit; ND-30-PA; complex I 30 kDa; nuclear-encoded subunit NDUFS3 of complex I

NP_647775.1

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The following sections contain reference sequences that belong to a specific genome build. Explain