U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Shab Shaker cognate b [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38352, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Shabprovided by FlyBase
Official Full Name
Shaker cognate bprovided by FlyBase
Primary source
FLYBASE:FBgn0262593
Locus tag
Dmel_CG43128
See related
AllianceGenome:FB:FBgn0262593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1066; CG43128; CG9965; Dmel\CG43128; dShab; Kv2; K[[v]]2; shab; shb
Old locus tag
Dmel_CG1066; Dmel_CG9965
Summary
Enables delayed rectifier potassium channel activity. Involved in several processes, including larval locomotory behavior; positive regulation of circadian sleep/wake cycle, sleep; and regulation of synaptic activity. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in alcohol dependence; developmental and epileptic encephalopathy 26; epilepsy; and retinal cone dystrophy 3B. Orthologous to several human genes including KCNB2 (potassium voltage-gated channel subfamily B member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Shab in Genome Data Viewer
Location:
63A1-63A2; 3-5 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2895017..2959579)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2895017..2959579)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44531 Neighboring gene spatzle 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 63a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutational analysis of the Shab-encoded delayed rectifier K(+) channels in Drosophila. Hegde P, et al. J Biol Chem, 1999 Jul 30. PMID 10419540
  2. Celecoxib and ion channels: a story of unexpected discoveries. Frolov RV, et al. Eur J Pharmacol, 2014 May 5. PMID 24630832
  3. Shab K (+) channel slow inactivation: a test for U-type inactivation and a hypothesis regarding K (+) -facilitated inactivation mechanisms. Carrillo E, et al. Channels (Austin), 2013 Mar-Apr. PMID 23419584, Free PMC Article
  4. Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. Herrera-Valdez MA, et al. J Comput Neurosci, 2013 Apr. PMID 22878689, Free PMC Article
  5. Inhibition of ion channels and heart beat in Drosophila by selective COX-2 inhibitor SC-791. Frolov RV, et al. PLoS One, 2012. PMID 22701705, Free PMC Article

See all (136) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Shab is a typical K channel that excludes Na
    Title: K⁺-dependent selectivity and external Ca²⁺ block of Shab K⁺ channels.
  2. Upon illumination, the delayed rectifier current mediated by Shab channels Drosophila photoreceptors was specifically increased.
    Title: Light-dependent modulation of Shab channels via phosphoinositide depletion in Drosophila photoreceptors.
  3. observations highlight crucial control of nerve terminal excitability by Shaker & Shab channels to confer temporal patterns of synaptic transmission & suggest participation of these channels in activity-dependent synaptic plasticity
    Title: Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
shaker cognate b
Names
CG43128-PA
CG43128-PB
CG43128-PC
CG43128-PH
CG43128-PI
CG43128-PJ
CG43128-PK
CG43128-PL
CG43128-PM
CG43128-PN
Shab-PA
Shab-PB
Shab-PC
Shab-PH
Shab-PI
Shab-PJ
Shab-PK
Shab-PL
Shab-PM
Shab-PN
shaker

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2895017..2959579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274416.1 → NP_001261345.1  shaker cognate b, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261345.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE38
    Conserved Domains (4) summary
    smart00225
    Location:309 → 416
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:501 → 700
    Ion_trans; Ion transport protein
    pfam02214
    Location:309 → 408
    BTB_2; BTB/POZ domain
    pfam07885
    Location:613 → 696
    Ion_trans_2; Ion channel

  2. NM_001202108.2 → NP_001189037.1  shaker cognate b, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189037.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRZ7
    Conserved Domains (4) summary
    smart00225
    Location:309 → 416
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:501 → 700
    Ion_trans; Ion transport protein
    pfam02214
    Location:309 → 408
    BTB_2; BTB/POZ domain
    pfam07885
    Location:613 → 696
    Ion_trans_2; Ion channel

  3. NM_001043115.3 → NP_001036580.1  shaker cognate b, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76805, P17970, Q9I7T9, Q9I7U0
    UniProtKB/TrEMBL
    Q0E8I8
    Conserved Domains (4) summary
    smart00225
    Location:309 → 416
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:501 → 700
    Ion_trans; Ion transport protein
    pfam02214
    Location:309 → 408
    BTB_2; BTB/POZ domain
    pfam07885
    Location:613 → 696
    Ion_trans_2; Ion channel

  4. NM_167967.4 → NP_728783.1  shaker cognate b, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728783.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76805, P17970, Q9I7T9, Q9I7U0
    Related
    FBpp0293731
    Conserved Domains (4) summary
    smart00225
    Location:309 → 416
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:501 → 700
    Ion_trans; Ion transport protein
    pfam02214
    Location:309 → 408
    BTB_2; BTB/POZ domain
    pfam07885
    Location:613 → 696
    Ion_trans_2; Ion channel

  5. NM_079170.6 → NP_523894.2  shaker cognate b, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523894.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76805, P17970, Q9I7T9, Q9I7U0
    Related
    FBpp0293732
    Conserved Domains (4) summary
    smart00225
    Location:309 → 416
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:501 → 700
    Ion_trans; Ion transport protein
    pfam02214
    Location:309 → 408
    BTB_2; BTB/POZ domain
    pfam07885
    Location:613 → 696
    Ion_trans_2; Ion channel

  6. NM_001202110.2 → NP_001189039.1  shaker cognate b, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189039.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE38
    Conserved Domains (4) summary
    smart00225
    Location:309 → 416
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:501 → 700
    Ion_trans; Ion transport protein
    pfam02214
    Location:309 → 408
    BTB_2; BTB/POZ domain
    pfam07885
    Location:613 → 696
    Ion_trans_2; Ion channel

  7. NM_001202109.2 → NP_001189038.1  shaker cognate b, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189038.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRU9
    Conserved Domains (4) summary
    smart00225
    Location:309 → 416
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:501 → 700
    Ion_trans; Ion transport protein
    pfam02214
    Location:309 → 408
    BTB_2; BTB/POZ domain
    pfam07885
    Location:613 → 696
    Ion_trans_2; Ion channel

  8. NM_001259656.2 → NP_001246585.1  shaker cognate b, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246585.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76805, P17970, Q9I7T9, Q9I7U0
    UniProtKB/TrEMBL
    M9ND32
    Conserved Domains (4) summary
    smart00225
    Location:309 → 416
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:501 → 700
    Ion_trans; Ion transport protein
    pfam02214
    Location:309 → 408
    BTB_2; BTB/POZ domain
    pfam07885
    Location:613 → 696
    Ion_trans_2; Ion channel

  9. NM_001259655.2 → NP_001246584.1  shaker cognate b, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246584.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76805, P17970, Q9I7T9, Q9I7U0
    UniProtKB/TrEMBL
    M9NFJ6
    Conserved Domains (4) summary
    smart00225
    Location:309 → 416
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:501 → 700
    Ion_trans; Ion transport protein
    pfam02214
    Location:309 → 408
    BTB_2; BTB/POZ domain
    pfam07885
    Location:613 → 696
    Ion_trans_2; Ion channel

  10. NM_001104015.4 → NP_001097485.3  shaker cognate b, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097485.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNI9
    Conserved Domains (4) summary
    smart00225
    Location:309 → 416
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:501 → 700
    Ion_trans; Ion transport protein
    pfam02214
    Location:309 → 408
    BTB_2; BTB/POZ domain
    pfam07885
    Location:613 → 696
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNI9 A8JNI9
M9MRU9 M9MRU9
M9MRZ7 M9MRZ7
M9ND32 M9ND32
M9NFJ6 M9NFJ6
M9PE38 M9PE38
P17970.2 P17970
Q0E8I8 Q0E8I8
Q95T71 Q95T71

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous