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Cyp4d20 Cytochrome P450 4d20 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38311, updated on 9-Dec-2024

Summary

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Official Symbol
Cyp4d20provided by FlyBase
Official Full Name
Cytochrome P450 4d20provided by FlyBase
Primary source
FLYBASE:FBgn0035344
Locus tag
Dmel_CG16761
See related
AllianceGenome:FB:FBgn0035344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4d20; CG16761; CYP4d20; Dmel\CG16761; RH59895
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Cyp4d20 in Genome Data Viewer
Location:
62E3-62E3; 3-3 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2476259..2478448, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2476259..2478448, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Supervillin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitotic spindle organizing protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ran participates in deltamethrin stress through regulating the nuclear import of Nrf2. Ge M, et al. Gene, 2021 Feb 15. PMID 33069802
  2. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Idda T, et al. Sci Rep, 2020 Dec 9. PMID 33299007, Free PMC Article
  3. Comparative CYP-omic analysis between the DDT-susceptible and -resistant Drosophila melanogaster strains 91-C and 91-R. Seong KM, et al. Pest Manag Sci, 2018 Nov. PMID 29656515
  4. dGLYAT modulates Gadd45-mediated JNK activation and cell invasion. Xu M, et al. Cell Div, 2022 Aug 6. PMID 35933447, Free PMC Article
  5. Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster. Coelho A, et al. PLoS One, 2015. PMID 25671424, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4d20
Names
CG16761-PA
Cyp4d20-PA
NP_647723.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2476259..2478448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139466.5 → NP_647723.2  cytochrome P450 4d20 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647723.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W011
    UniProtKB/TrEMBL
    H8F4S6, Q8SZ48
    Related
    FBpp0072837
    Conserved Domains (1) summary
    pfam00067
    Location:34 → 493
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SZ48 Q8SZ48
Q9W011.1 Q9W011

Gene LinkOut

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