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dre4 - dre4

Enables nucleosome binding activity and protein heterodimerization activity. Involved in positive regulation of transcription elongation by RNA polymerase II and regulation of chromatin organization. Located in cytosol; nucleolus; and polytene chromosome puff. Part of FACT complex. Colocalizes with polytene chromosome interband. Is expressed in adult head and spermatozoon. Used to study neurodevelopmental disorder with dysmorphic facies and thin corpus callosum. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and thin corpus callosum. Orthologous to human SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa