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CG12020 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38233, updated on 4-Jan-2025

Summary

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Official Symbol
CG12020provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035273
Locus tag
Dmel_CG12020
See related
AllianceGenome:FB:FBgn0035273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12020
Summary
Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in cytosol. Is expressed in eye and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 34. Orthologous to human DNAJB13 (DnaJ heat shock protein family (Hsp40) member B13). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG12020 in Genome Data Viewer
Location:
62B4-62B4; 3-1.0 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1797305..1798610)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1797305..1798610)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene alpha Spectrin Neighboring gene discs lost Neighboring gene antisense RNA:CR45818 Neighboring gene Cell division cycle 37 Neighboring gene patj Neighboring gene uncharacterized protein Neighboring gene JTBR Neighboring gene antisense RNA:CR45686

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye. Richard M, et al. Dev Dyn, 2006 Apr. PMID 16245332
  2. The Drosophila cell survival gene discs lost encodes a cytoplasmic Codanin-1-like protein, not a homolog of tight junction PDZ protein Patj. Pielage J, et al. Dev Cell, 2003 Dec. PMID 14667407
  3. Domain-specific early and late function of Dpatj in Drosophila photoreceptor cells. Nam SC, et al. Dev Dyn, 2006 Jun. PMID 16518799
  4. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Deo A, et al. Sci Rep, 2024 Sep 6. PMID 39242711, Free PMC Article
  5. A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. Xu H, et al. EMBO J, 2004 Feb 25. PMID 14963491, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12020-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1797305..1798610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139405.1 → NP_647662.1  uncharacterized protein Dmel_CG12020 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647662.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RIE0, Q9W083
    Related
    FBpp0072661, FBtr0072778
    Conserved Domains (3) summary
    cd10747
    Location:156 → 335
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:7 → 352
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:7 → 87
    DnaJ; DnaJ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W083 Q9W083

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