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Mettl2 Methyltransferase like 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38197, updated on 9-Dec-2024

Summary

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Official Symbol
Mettl2provided by FlyBase
Official Full Name
Methyltransferase like 2provided by FlyBase
Primary source
FLYBASE:FBgn0035247
Locus tag
Dmel_CG13929
See related
AllianceGenome:FB:FBgn0035247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey109; CG13929; Dmel\CG13929; metl; Metl; METTL2A; METTL2B
Summary
Predicted to enable tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Is expressed in organism. Orthologous to several human genes including METTL2A (methyltransferase 2A, tRNA N3-cytidine) and METTL2B (methyltransferase 2B, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Mettl2 in Genome Data Viewer
Location:
62A9-62A9; 3-0.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1637942..1639235, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1637942..1639235, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene gamma-glutamyl carboxylase Neighboring gene uncharacterized protein Neighboring gene neuronal Synaptobrevin Neighboring gene Coat Protein (coatomer) alpha Neighboring gene Big brother

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins. Zhang SX, et al. Gene, 2001 Dec 12. PMID 11738826
  2. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article
  3. MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila. Daneshvar K, et al. Biol Open, 2013 Jan 15. PMID 23336071, Free PMC Article
  4. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
  5. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tRNA (cytidine) methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA (cytidine-3-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tRNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
methyltransferase like 2
Names
CG13929-PA
CG13929-PB
Mettl2-PA
Mettl2-PB
methyltransferase-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1637942..1639235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167907.3 → NP_728647.2  methyltransferase like 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728647.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    F2FB75
    Related
    FBpp0072695
    Conserved Domains (2) summary
    COG0500
    Location:72 → 301
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:115 → 217
    Methyltransf_12; Methyltransferase domain

  2. NM_139379.4 → NP_647636.3  methyltransferase like 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647636.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86BS6, Q960S9, Q9W0C0
    Related
    FBpp0072696
    Conserved Domains (2) summary
    COG0500
    Location:95 → 324
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:138 → 240
    Methyltransf_12; Methyltransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86BS6.2 Q86BS6

Gene LinkOut

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