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Vmn2r43 vomeronasal 2, receptor 43 [ Mus musculus (house mouse) ]

Gene ID: 381838, updated on 27-Nov-2024

Summary

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Official Symbol
Vmn2r43provided by MGI
Official Full Name
vomeronasal 2, receptor 43provided by MGI
Primary source
MGI:MGI:3037819
See related
Ensembl:ENSMUSG00000053720 AllianceGenome:MGI:3037819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1961; EC2-V2R
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Vmn2r43 in Genome Data Viewer
Location:
7 A1; 7 5.76 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (8247347..8263598, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (8244348..8260599, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 41 Neighboring gene vomeronasal 2, receptor 42 Neighboring gene predicted gene 3654 Neighboring gene vomeronasal 2, receptor, pseudogene 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules. Loconto J, et al. Cell, 2003 Mar 7. PMID 12628182
  2. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vomeronasal 2, receptor 43
Names
EC2-V2R pheromone receptor
vomeronasal receptor Vmn2r43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198961.3 → NP_945199.1  vomeronasal 2, receptor 43 precursor

    See identical proteins and their annotated locations for NP_945199.1

    Status: VALIDATED

    Source sequence(s)
    AC165963, AC188454
    Consensus CDS
    CCDS57484.1
    UniProtKB/TrEMBL
    K7N652, Q80Z08
    Related
    ENSMUSP00000069647.5, ENSMUST00000066317.5
    Conserved Domains (4) summary
    pfam00003
    Location:583 → 817
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:75 → 429
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:497 → 548
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:39 → 487
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    8247347..8263598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322322.1 → XP_017177811.1  vomeronasal 2, receptor 43 isoform X1

    UniProtKB/TrEMBL
    K7N652
    Conserved Domains (3) summary
    cd15283
    Location:585 → 836
    7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:512 → 565
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06365
    Location:43 → 503
    PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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