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SA2 Stromalin 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38167, updated on 4-Jan-2025

Summary

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Official Symbol
SA2provided by FlyBase
Official Full Name
Stromalin 2provided by FlyBase
Primary source
FLYBASE:FBgn0043865
Locus tag
Dmel_CG13916
See related
AllianceGenome:FB:FBgn0043865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0109301.35; CG1; CG13916; Dmel\CG13916; DSA2; pf-1; SA-2; snm; SNM
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in sister chromatid cohesion. Colocalizes with condensed nuclear chromosome and nucleolus. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked; Mullegama-Klein-Martinez syndrome; autosomal dominant intellectual developmental disorder 47; primary ovarian insufficiency 8; and spermatogenic failure 61. Orthologous to human STAG1 (STAG1 cohesin complex component); STAG2 (STAG2 cohesin complex component); and STAG3 (STAG3 cohesin complex component). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See SA2 in Genome Data Viewer
Location:
62A1-62A1; 3-0.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1434336..1437872, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1434336..1437872, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase 61F Neighboring gene alpha1,3-fucosyltransferase D Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44842 Neighboring gene rhomboid

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Meiotic pairing and disjunction of mini-X chromosomes in drosophila is mediated by 240-bp rDNA repeats and the homolog conjunction proteins SNM and MNM. Thomas SE, et al. Genetics, 2007 Oct. PMID 17660566, Free PMC Article
  2. Homologous pairing and the role of pairing centers in meiosis. Tsai JH, et al. J Cell Sci, 2011 Jun 15. PMID 21625006
  3. From early homologue recognition to synaptonemal complex formation. Zickler D. Chromosoma, 2006 Jun. PMID 16570189
  4. Sex Chromosome Pairing Mediated by Euchromatic Homology in Drosophila Male Meiosis. Hylton CA, et al. Genetics, 2020 Mar. PMID 31915134, Free PMC Article
  5. When size does not matter: pairing sites during meiosis. McKim KS. Cell, 2005 Dec 16. PMID 16360029

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identification of Stromalin in Meiosis SNM) and Modifier of Mdg4 in Meiosis (MNM) required for conjunction and regular segregation in meiosis
    Title: Identification of two proteins required for conjunction and regular segregation of achiasmate homologs in Drosophila male meiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stromalin 2
Names
CG13916-PC
SA2-PC
Stromalin-2
complementation group 1
pairing failure-1
stromalin in meiosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1434336..1437872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138265.3 → NP_612109.3  stromalin 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612109.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3S4X5, Q9W0F4
    Conserved Domains (1) summary
    pfam08514
    Location:134 → 217
    STAG; STAG domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3S4X5 Q3S4X5
Q8T8V6 Q8T8V6
Q9W0F4 Q9W0F4

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