Rbm33 RNA binding motif protein 33 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbm33provided by MGI
Official Full Name: RNA binding motif protein 33provided by MGI
Primary source: MGI:MGI:1919670
See related: Ensembl:ENSMUSG00000048271 AllianceGenome:MGI:1919670
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prr8; 3200001K10Rik; 6430512A10Rik
Summary: Predicted to enable N6-methyladenosine-containing RNA reader activity and lncRNA binding activity. Predicted to be involved in RNA export from nucleus and regulation of mRNA stability. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in head; limb; and trunk. Orthologous to human RBM33 (RNA binding motif protein 33). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 22.3), CNS E14 (RPKM 16.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 14.36 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (28521817..28624242)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (28316836..28419244)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury.
Title: CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235147

C76498 (e-PCR)
- UniSTS:207763

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables N6-methyladenosine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in RNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RNA-binding protein 33

Names: proline rich 8; proline-rich protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028234.1 → NP_082510.1 RNA-binding protein 33

See identical proteins and their annotated locations for NP_082510.1

Status: PROVISIONAL

Source sequence(s)

AC134530, AK014289, AK153360, BB637766, CB528202, CN703034

Consensus CDS

CCDS51448.1

UniProtKB/Swiss-Prot

Q3U5Z3, Q8C5J6, Q9CXK9

Related

ENSMUSP00000062449.7, ENSMUST00000059644.13

Conserved Domains (1) summary

cd00590
Location:1161 → 1226

RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

28521817..28624242

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535733.5 → XP_006535796.1 RNA-binding protein 33 isoform X1

Conserved Domains (5) summary

PHA03418
Location:451 → 491

PHA03418; hypothetical E4 protein; Provisional

COG5271
Location:15 → 238

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

PRK09510
Location:802 → 873

tolA; cell envelope integrity inner membrane protein TolA; Provisional

PRK14086
Location:456 → 618

dnaA; chromosomal replication initiator protein DnaA

cd00590
Location:1160 → 1225

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006535734.5 → XP_006535797.1 RNA-binding protein 33 isoform X2

UniProtKB/TrEMBL

D3Z5I9

Related

ENSMUSP00000110534.2, ENSMUST00000114884.8

Conserved Domains (6) summary

PHA03418
Location:411 → 451

PHA03418; hypothetical E4 protein; Provisional

PHA03247
Location:398 → 688

PHA03247; large tegument protein UL36; Provisional

COG5271
Location:15 → 200

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

PRK09510
Location:762 → 833

tolA; cell envelope integrity inner membrane protein TolA; Provisional

cd00590
Location:1121 → 1186

RRM_SF; RNA recognition motif (RRM) superfamily

pfam09770
Location:417 → 538

PAT1; Topoisomerase II-associated protein PAT1
XM_006535735.5 → XP_006535798.1 RNA-binding protein 33 isoform X3

Conserved Domains (6) summary

PHA03418
Location:411 → 451

PHA03418; hypothetical E4 protein; Provisional

PHA03247
Location:398 → 688

PHA03247; large tegument protein UL36; Provisional

COG5271
Location:15 → 200

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

PRK09510
Location:762 → 833

tolA; cell envelope integrity inner membrane protein TolA; Provisional

cd00590
Location:1120 → 1185

RRM_SF; RNA recognition motif (RRM) superfamily

pfam09770
Location:417 → 538

PAT1; Topoisomerase II-associated protein PAT1