Ptp61F - Protein tyrosine phosphatase 61F

Enables non-membrane spanning protein tyrosine phosphatase activity and protein sequestering activity. Involved in several processes, including cellular response to mechanical stimulus; germ-band extension; and negative regulation of signal transduction. Located in mitochondrial envelope; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult head; central brain primordium; male germline cell; and somatic cell of testis. Used to study intestinal cancer. Human ortholog(s) of this gene implicated in coronary artery disease; essential hypertension; and type 2 diabetes mellitus. Orthologous to several human genes including PTPN2 (protein tyrosine phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

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